@garyfritz, you might ask your doctor to consider a larger dose on mB12 as "more support", and to inject the larger dose every day, at least for a while. IMO 1mg every few days isn't enough. The half-life of mB12 in the body is pretty short, especially in cases of deficiency. For a while I was doing a dose of 0.4ml of injectable per day, which gave me 5mg/day of mB12. (BTW, the amount you inject doesn't really have anything to do with how many mg of B12 you get...mg of B12 per ml depends upon how they formulate the solution). I did 5mg/day for a couple of months (after doing 1-3mg/day for several months before that) before I felt like I was "topped out" and felt as good on a reduced dose. Point being, it took a while of big doses daily for me to feel like I didn't need that much B12. Everyone's different, but throwing it out there for you in case it might work for you. Also, please keep in mind that you may have already had your B12 "aha" moment with the Readisorb. @sueami and I got the "aha" off our first injections, but we were likely coming from a place of almost absolute deficiency. I definitely was. You likely were not...you'd had a boost/good reaction to the Readisorb so you'd gotten a bit of your deficiency taken care of with that. So you may not get the big boost that we did from the injections. I think when you get the right amount of B12 and other stuff titrated you will definitely see improvement, but you may not ever get the "revelatory buzz". I wish I would get the same buzz off every shot as I did that first one, but unfortunately it doesn't work that way. Things still get better with continued injections, but the reaction is just a lot more subtle. Just sayin'. It could also be that the B12 they injected you with at the doctor's office *was* degraded. If it was degraded to cyanocobalamin or even hydroxy maybe it wouldn't do you any good. I do hope you get an aha off the first injection you give yourself from your fresh vial at home. Just don't be unduly disappointed if you don't.