Meta-analysis investigating post-exertional malaise between patients and controls (Brown and Jason, 2018)

Pyrrhus

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This paper establishes Post-Exertional Malaise (PEM) as a cardinal symptom in ME.
(I don't think this paper from 2018 has been discussed yet.)

Meta-analysis investigating post-exertional malaise between patients and controls
https://journals.sagepub.com/doi/10.1177/1359105318784161
Excerpt:
Brown and Jason 2018 said:
Post-exertional malaise is either required or included in many previously proposed case definitions of myalgic encephalomyelitis/chronic fatigue syndrome. A meta-analysis of odds ratios (ORs; association between patient status and post-exertional malaise status) and a number of potential moderators (i.e. study-level characteristics) of effect size were conducted.

Post-exertional malaise was found to be 10.4 times more likely to be associated with a myalgic encephalomyelitis/chronic fatigue syndrome diagnosis than with control status. Significant moderators of effect size included patient recruitment strategy and control selection. These findings suggest that post-exertional malaise should be considered a cardinal symptom of myalgic encephalomyelitis/chronic fatigue syndrome.
 
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