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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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What adreno is trying to say, maybe in a not very empathic way, is that the problems you are talking about are highly unlikely to be solely due to one gene. Especially if there's no evidence that the gene variation causes those issues, which you can easily research and see for yourself.Oh well. I've spent a lot of time over this year looking into this issue. I've come to different conclusions from you.
http://en.wikipedia.org/w/index.php?title=Histamine#Synthesis_and_metabolismOnce formed, histamine is either stored or rapidly inactivated by its primary degradative enzymes, histamine-N-methyltransferase or diamine oxidase. In the central nervous system, histamine released into the synapsesis primarily broken down by histamine-N-methyltransferase, while in other tissues both enzymes may play a role. Several other enzymes, including MAO-B and ALDH2, further process the immediate metabolites of histamine for excretion or recycling.
You are right that the G allele is the high activity variant. However, the T allele is not slowed down, it's the normal variant. It means your MAO A has normal activity. See:http://snpedia.com/index.php/Rs6323
I don't know why Yasko et al. has this as a risk allele. In all studies, the G allele is the risk allele.
MAO A's role is at least two fold: break down excitatory neurotransmitters (noradrenaline and dopamine) in the brain and break down Tyramine in the gut.I'm really not sure what the MAO mutation really entails. That's what I was hoping we could figure out.
Methylation supplements really send me into depression.
Did macuna help you? It was far too stimulating for me as it appeared my body couldn't remove the dopamine. I have an MAO aberration as well and dopamine seems awful for me.I have MAO A ++ and have moodswings, irritability, random sadness, and have had panic attacks daily and anxiety for 7 years. I'm honestly not sure what to do anymore. I've been on 5htp, macuna, evening primrose oil, lithium orotate 5 mg, and other things that my doc has used to stabalize my neurotransmitters. Last urine test last year before I stopped almost all of it, my dopamine and seratonin were high, so I know it was working, just not helping in the way I needed it. I'm going to Mensah Medical in a few weeks so hopefully they can help there.
It might not be just this gene that is causing the problem, but something else in your constitution. I am MAO TT and I am coming to the same conclusion as you, but perhaps the MAO TT is a red herring. Have you found anything useful to upregulate MAO? My neurotransmitters appear to need supplementation up to a point. However, after a few days I think too much builds up and I can't sleep.Oh well. I've spent a lot of time over this year looking into this issue. I've come to different conclusions from you.
I haven't even thought of MAO in the years since the post. What I can say is that since my 2nd round of Candida cleanse, a year ago, all my symptoms have lessened. I feel like I've removed all the drag on my system, w/ diet, detox, supplementation, and what's left is the debility of ME. I'm less reactive than I was throughout my life, having almost no histamine reactions. more stable than I've been, maybe ever. Just not enough energy to do much. cheers.Have you found anything useful to upregulate MAO?