I don't think that there's anything there which really reflects badly on anyone. It was a bit frustrating to listen to, but I thought the crowd's comments were not unreasonable so much as ill-timed. And Coyne dealt with things well (other than starting by saying people could interrupt at any time... bad James Coyne).
It was probably too early for Coyne to be able to do a great video for activism aimed at those outside of patients, and in some ways it seemed that it was aimed more at us than others. I thought he made a lot of good points, and in some ways, I thought he had a better understanding of the politics than the patients who were discussing things with him. I think that Britain is such a deferential society that the politics of science matter more to us than the politics of the street. I felt like Coyne didn't want to do too much to contradict the patients on this, and maybe felt that it wasn't his place, but I'd have liked to hear more from him on this.
All sounds very hopeful to me. Great work to everyone involved in making this talk happen... and that includes everyone working over the years to carefully uncover problems with the biopsychosocial approach to CFS, and introduce these problems to people like Coyne. Fingers crossed we're getting some real traction now. I think that their excuses have already been picked apart, and as soon as we had some people on-side with the authority to insist on real debate, the whole BPS project could crumble pretty quick.