elpha.....it isn't just bacteria at play. something is causing the inflammation that is causing the bacteria to become imbalanced, and creating this feedback loop. I think this is HERV. this explains why they keep finding retroviral sequences but no retrovirus. it explains why people seem to get better on some treatment or other, but do not stay better. it explains why GcMAF and HIV medications sometimes help. the bacterial imbalances, leaky gut, systemic inflammation, all of it...are downstream effects.
something has activated HERV in autism, MS, Lupus, CFS, etc etc.
diet and probiotics can ameliorate disease process but will not stop disease. we need monoclonal antibody against the ENV protein of the HERV.
Hi Daffodil, it is good to see people who actually take an interest in all this and I am only new but the last 4 people who told me something similar to what you just put to me are now heading into court for medical negligence and misdiagnosis ..... Let me please throw all the 'opinions' out the window and let's talk about actual science ....
1. Leaky gut is a bowel infection caused by pathogenic bacteria
2. Leaky gut allows lactic acid, toxins and H2S to pass into the bloodstream creating all sorts of body reactions which I am quite happy to expand on if you wish (please look up acidosis and Hydrogen Sulfide poisoning) .....
Streptococcus, Enterococcus and Lactobacillus, are, under
aerobic conditions, able to produce amounts of hydrogen
peroxide comparable to those released by cells of the
immune system during the oxidative burst[15]. This additional
source of hydrogen peroxide could help sustain,
or even exacerbate, gut inflammation[16]. Notably, certain
Enterococcus strains can defend themselves against the surplus
of reactive oxygen species (ROS) by producing antioxidative
enzymes to increase their chances of survival in
unfavourable conditions[17]
3. The pathogenic bacteria (and viruses) causes an inflammation with the release of cytokines such as interleukin 1a, 6, 8 etc. along with antibodies to greet the invading bacteria .... The prolonged auto-immune response then attacks internal organs such as the thyroid, pancreas, kidneys (i will further expand on this one). liver, cartilage and the nervous system.
So why does this happen?? I am glad you asked .... Let's talk about the normal relationship ...Normal flora (bacteria) have a symbiotic relationship with their host, They are able to attach themselves to the epithelial cells via receptors, this is how the body uses the bacteria ... and how the bacteria uses the body ..... Now this is what I will call the missing link that everybody has been searching for .....
During times of stress (ie when attacked by antibiotics) normal flora swap genetic material (plasmids) between themselves and pathogenic bacteria and the survival genes encoded within them turn on and they turn into pathogens. When they become pathogens ... they are also infectious and are able to be passed onto others via close personal contact ....
This is why that a lot of us start off with a sore throat, vaginitis, prostatitis, urethritis or some other inflammation that when swabbed returns normal flora and antibiotics don't work ....
I will concentrate only on enterococcus and streptococcus (viridans) or I will be here doing a thesis.
In order for a strain to be pathogenic, it must be able to breech the epithelial layer and invade the underlying cells ... over 60% of strains contain gelatinase which dissolves the gelatin within the epithelial layer allowing the bacteria to invade the underlying cell and cause an inflammatory response ....... LTA and
Lipopolysaccharides LPS are prolific causes of inflammation
LPS function has been under experimental research for several years due to its role in activating many transcription factors. LPS also produces many types of mediators involved in septic shock. Humans are much more sensitive to LPS than other animals (e.g., mice). A dose of 1 µg/kg induces shock in humans, but mice will tolerate a dose up to a thousand times higher.[13]This may relate to differences in the level of circulating natural antibodies between the two species.[14][15] Said et al. showed that LPS causes an IL-10-dependent inhibition of CD4 T-cellexpansion and function by up-regulating PD-1 levels on monocytes which leads to IL-10 production by monocytes after binding of PD-1 by PD-L.[16]
Bruce Beutler was awarded a portion of the 2011 Nobel Prize in Physiology or Medicine for his work demonstrating that TLR4 is the LPS receptor
Recent studies on the pathogenicity of enterococci
indicate that the genomes of strains that are able to
cause tissue damage and inflammation contain a pathogenicity
island that encodes aggregation substance (AS),
gelatinase, extracellular surface proteins (Esp), cytolysin,
hyaluronidase and other proteins[8,9]. Enterococci that express
AS were found to resist phagocytosis significantly
better than an isogenic AS-negative strain by inhibiting
the respiratory burst of macrophages[10]. Gelatinase, a
protease produced by enterococci, is capable of hydrolysing
gelatin, collagen, casein, haemoglobin and other
peptides[9]. The Esp enhance biofilm formation in E.
faecalis[11]. Cytolysin produced by the enterococci is lethal
for a broad range of prokaryotic and eukaryotic cells[12].
Hyaluronidase is mainly a degradative enzyme that is associated
with tissue damage[13].
Your gut is like a brick wall and depending on what enzymes the bacteria is carrying, depends on how much damage it does. so, like any brick wall .... you start knocking out bricks and you start having holes in the wall .... Simple science really ...
And the real beauty of all this is that they are happy to share their pathogenic traits with others, so then you get an army of bacteria attacking you .... I reckon that would make you sick .... makes me sick ....
Viridans streptococcus also classed as consensual flora picks up the same enzymes and are non pyogenic (non puss forming) and always return as normal flora from a commercial lab .... So they hide in plain site ...
These bugs are potential superbugs .... they become resistant to macroloides and doxycyclene in as little as a week .... the reason why nobody is cured is because you need 8+ weeks of multiple antibiotics to remove the offending bacteria ... short doses just build resistance as it doesn't break through the biofilms ... This Dr Demeirler treatment is the closest I have seen to a solution, but it isn't quite there and it ultimately builds totally resistant superbugs ....
probiotics don't work as the bacteria aren't attached to the receptors, they are inside the cells .... the role of probiotics is to take over the receptors and supposedly stopping the pathogens from being able to hook up ..... WRONG!!!! The nasties are living in the cells and can't be shifted .... Bugger :/
Your sore throat, vaginitis, sore eyes, prostatitis, rosacea, and sore bowel are from an infection with bacteria that have turned against you but have slipped under our medical professions radar .... And I can scientifically prove it .... It has been proven in the literature already ....
Your theory may be right, except for the leaky gut part .... but I am going with the scientific facts, and I know I will feel much better when my gut is fixed ....
BTW .... how do I know this .... because after 3 years of prostatitis and chronic sore throat, I put saliva on my finger and stuck it up my rectum ... within a week I had severe IBS .... and now I am having a complete auto-immune system breakdown .... But I have normal flora ....
And the reason women have higher incidence of IBS and CFS .... it is because bacteria escape from the vagina and run into the anus in fluids .... and I am not going into how pathogenic mouth bugs could get into a vagina in an open forum .... My 8 year old daughter has had a chronic sore throat and swollen glands in her neck for the past 2 years .... When her vagina started burning like her mums ... I lost my sense of humour .... doxycyclene + azithromycin stopped it finally ..... same for my wife .....
Fire your questions .... I have over 50 papers here that supports what I have just put here ....
