The methylation cycle depends on a number of vitamins in the B complex. Namely: B12, B9, B6, B2 and B3.
Are there specific reasons why you need to get your methylation cycle run well? Diet typically can make it run well, unless labs say otherwise. Do they?
cheers
In a nutshell, I really couldn't tolerate sulfuric foods for a long time (I'd have hummus and be just wiped out and irritable the next day), and I've had off/on issues with being super fatigued. I'm known by my friends as having bad allergies, strange food reactions, and fatigue. I had a 23andme test, which turned up compound heterozygous MTHFR. I respond incredibly well to B12 and a B complex initially, despite my B12 levels being in check. I do eat a pretty balanced diet I'd say too. This has been an ongoing quest for me for a long time.
This is my most recent attempt to get methylation running well, and it's the closest I've ever gotten. I've gotten up to 1mg mb12, 750mcg adB12, about 8mg mFolate, and now I'm trying to get a B complex in. It's tougher than I thought - looking at my logs, the past 5 days with a B complex have turned my mood for the worse, despite a boost in energy. My acne has gotten much worse than baseline during the past few days too.
Basically wondering how likely it is that my diet is satisfying my needs for B1/B2/B3/B6/B7, and if a B complex is just pushing me over the top.
I've removed the B complex now, going to let things settle for a few days, then consider a fresh B blood test and/or the super-low Nature Made B complex.