jjxx
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Simply moly....DO you know what has changed it?
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Simply moly....DO you know what has changed it?
Revisiting this thread after going downhill big time in the last year and a half -- realizing that I probably stopped or slowed down my folinic acid intake due to misinterpreting this study -- I was doing 'better' at least in some ways on the folinic, but stopped taking it on a regular basis about August of last year.
Thanks again to @Victronix for posting the full study. I wish I had analyzed it in more detail last year, as it seems that the author's conclusions just don't wash.
They say: "Folate binds to and is transported into cells by the rFC-1 trans- porter.8 High-dose folic acid supplementation might exacerbate thiamine deficiency at susceptible sites, such as the kidney and vascular cells in diabetic nephropathy, by competing with tmP and tPP and impairing their uptake into tissues, thereby inhibiting sharing of thiamine metabolites between tissues rich in thiamine and those deficient in it."
But the study they reference says "Although the reduced folate carrier RFC1 and the thiamine transporters THTR-1 and THTR-2 share approximately 40% of their identity in protein sequence, RFC1 does not transport thiamine and THTR-1 and THTR-2 do not transport folates." But then they go on to say that in murine leukemia cells the folate receptor "may be one of the alternative transport routes available for TMP in some tissues when THTR-1 is mutated in the autosomal recessive disorder thiamine-responsive megaloblastic anemia."
And finally, it turns out there are several folate receptors, not just one, which of course makes sense. Who knows, there are probably several more they don't even know about...
http://en.wikipedia.org/wiki/Folate_receptor
So…I'm sorry I started this thread in the first place. Sheesh...
I also believe there is a major role for thiamine deficiency in my mother's dementia which is being called Alzheimer's but looks EXACTLY like B1 insufficiency to me ... I'm dosing her w multiple forms of B1 and would welcome advice on how to help B1 enter the brain if anyone has researched this.
I'm dosing her w multiple forms of B1 and would welcome advice on how to help B1 enter the brain if anyone has researched this.
As per Dr Lonsdale magnesium/potassium aspartateI'm dosing her w multiple forms of B1 and would welcome advice on how to help B1 enter the brain if anyone has researched this.
Thank you, Asklipia.As per Dr Lonsdale magnesium/potassium aspartate
Do you use Sulbutiamine? This crosses the BBB.
HA - I'm new to this forum and apparently don't have the hang of the REPLY function yet. Please forgive!She takes atenolol twice daily but seems to need less since I've been giving her Benfotiamine.
Yes and no. You do not feel the effects in such a spectacular manner but I think it still works. Some people do 20 days on 20 days off to restore the initial feelings (source: the chemist around the corner who used it to pass his exams!!). In general people tend to forget there is a PULSE to everything, most probably linked to the stars and also to the light and colours. Thiamine seems to help to connect to it.Sulbutiamine looks highly promising but seems to build tolerance and lose efficacy in just a matter of days. Is there a way around this?
It is true that TPP is the active form of thiamine within cells but supplementing it is no advantage.
Phosphorylation of substances is a good way of keeping them inside the cell since the presence of the phosphate group prevents them crossing membranes. This applies in the reverse direction also so that phosphorylated vitamins such as TPP have the phosphate groups clipped off by a phosphatase enzyme to enable them to be taken up from the intestine.
There is no advantage to taking TPP, you would be much better off sticking to a mixture of benfotiamine and one of the allithiamines.
What about sublingual TPP? I noticed a distinct advantage over 'regular' thiamine, when I used the Source Naturals sublingual, which is the TPP form.
This article says folate deficiency can cause thiamine deficiency. I'm really not sure what to believe.
I think the whole area of sublingual active vitamins is very murky. There are almost no studies to know what is really going on.
Even if they are taken up directly into the blood they still have to get into cells and the presence of phosphate group interferes with this. One needs to postulate a different uptake mechanism for which there is little evidence, though maybe a few hints from a small study I once read on B6 (and now can't find).
Having said that I did for a short while find that I got a very positive response to sublingual active B2 and B6 that I didn't seem to get with swallowed plain or active forms of the vitamins.
But this was only for a short while. I now take plain B2 and B6 swallowed.
So if there is any advantage to sublingual active vitamins the mechanism is unknown, but if they seem to be more beneficial for any individual, then go for it.
Why would nature make it more difficult for the active forms to be utilized?
Can anyone comment on Andy cutlers views on TTFD here: (taken from onibasu wiki)