@Hip I remember enjoying kava before I got sick, and I often use gabapentin or more infrequently ativan to help w me/cfs symptoms, but even though I have good kava (borogu and a couple of the others from kwk) i seem to get weirdly stimulated by it without heavy relaxation.
That's strange that you should get stimulated on kava. I found a comment here
that may be relevant:
From a general drug comparison, I view high kavain as the 'stimulant' type kava and high dhm as the 'depressant' type kava
I don't know if you find the stimulant effects good or not, but if you don't find them desirable, then perhaps a low kavain kava might suit.
Though looking at the chemotype list, it seems most commercially available kavas have 4 in the first or second position (kavain = 4). It does not look like low kavain kavas are common. But a kava with 4 in the second position in the chemotype figure should be slightly less simulating than a kava with 4 in the first position.
the thing is I mainly want to use it to keep my gabaergic tolerance somewhat low. I wonder if there are other things that actually reduce gabaergic tolerance. could the overstimulation be from alkaloid 1/mao-b?
I've never found anything that can reduce the tolerance build-up of benzodiazepines or other GABA system drugs. There is an interesting article here
about possible strategies to reduce opioid tolerance, ethanol tolerance, stimulant tolerance and nicotine tolerance — but unfortunately it says nothing about reducing GABA system tolerance.
I found this story
of a patient who took both Xanax and kava for 3 days in a row interesting: that combo caused so much GABA activation that he/she went into a coma! It suggests that kava can have strong GABAergic effects, but we know that kava is not addictive, so it may be a better alternative than benzodiazepines for some people.
Absolutely AWESOME, terrific, extremely helpful post
Glad you find it useful. Actually, all that info I posted was just online research on kava kava I did for myself, and which I noted down on my computer. So it was just a case of copying and pasting it.
I've made notes on my computer on so many subjects, so my computer has ended up being infinitely more knowledgable than me! Due to ME/CFS my memory has become so bad that no matter how much research I do, I always forget 90% within a few weeks. But my computer never forgets.