How do you know your viruses specifically raised IFN-g?
Can IFN-g not also be a marker of autoimmunity?
And what effect would IFN-g have that would create PEM? Peroxynitrite production?
Is it likely for a viral infection (that causes the usual viral symptoms) to not increase IFN-g? I assumed it as a given. As I understand it, IFN-g is one of the main factors responsible for what we feel as viral infection symptoms.
It might be caused by autoimmunity as well, but what I observed is that acute reactions (viral infections, muscle damage) triggered the same increase in ME symptoms, and also that an increase in TRP caused a similar increase in symptoms. All three are consistent with an increase in symptoms caused by kynurenine production. It's not a proven theory, but it does fit, and I haven't seen any theories that I like better.
IFN-g would increase IDO, which would increase kynurenine production. The symptoms do fit those caused by some of the nastier kynurenines, such as QUIN. I also had trouble with neurochemically-induced suicidal moods, which also fits with excess QUIN, and elevated MIPS (and TSH) which fits with elevated picolinic acid. Overall, my observations fit elevated kynurenines, and none of the observations contradict it, so it's still my top theory.