- Messages
- 68
Good afternoon,
first of all I totally agree with what @Hip says.
The difference between people who develop a disease associated with EBV and those who don't depends on some genetic factors that we will discuss in the study. But this is not only the case with this virus, but with many more and above all intracellular pathogens. The problem with all the research that has tried to link CFS with EBV or multiple sclerosis with EBV is that they are looking for copies of the virus and in reality the problem is found in the cells with latency of this virus. These latent cells, along with your genetics, are what cause the immune alteration.
Currently when it comes to taking patients for a study on CFS / ME are not divided into subgroups by pathogens hence no conclusive results are found. It also does not take into account the years with the disease, since a person newly ill with CFS / ME is not the same as one who has 20 years with the disease. The results would also be different.
Here is an example of HIV. When a person is infected with HIV, AIDS takes 10 years to appear. And during these years you go through different stages. After the acute infection, there is a latent clinical infection, with persistent swelling of the lymph nodes. Then it passes to the symptomatic stage where latent virus reactivations begin to appear, such as herpesvirus, fungal infections, diarrhea, weight loss, but not yet AIDS. This is the stage that resembles CFS/ME patients.
Then we move on to the AIDS stage, which is when CD4 lymphocytes start falling below 200 (it takes 10 years from when you become infected with HIV until you have AIDS).
That is, if we catch patients newly infected with the HIV virus and those who already have AIDS, the immunological results are different.
This is what we have seen in the analysis provided by the patients. Where patients who had been with the disease for more years had low levels of CD4 and CD8. But the patients who had been for a few years had these normal values and only low activated T lymphocytes. All of this is what we want to verify in the study and I would appreciate your help with fundraising and outreach. Because like you I am also sick and I want this to be verified as soon as possible. If our hypothesis is fulfilled we will have an acquired immunodeficiency diagnosis. This would allow us to seek specific treatment, such as what is currently being done to eliminate HIV.
With a little that each sick person, family or friends donate in a few days, the total could be collected.
Thank you very much in advance,
Greetings,
Manuel
Pd:If our hypothesis is confirmed we have another diagnostic method to confirm the results in another study.
first of all I totally agree with what @Hip says.
The difference between people who develop a disease associated with EBV and those who don't depends on some genetic factors that we will discuss in the study. But this is not only the case with this virus, but with many more and above all intracellular pathogens. The problem with all the research that has tried to link CFS with EBV or multiple sclerosis with EBV is that they are looking for copies of the virus and in reality the problem is found in the cells with latency of this virus. These latent cells, along with your genetics, are what cause the immune alteration.
Currently when it comes to taking patients for a study on CFS / ME are not divided into subgroups by pathogens hence no conclusive results are found. It also does not take into account the years with the disease, since a person newly ill with CFS / ME is not the same as one who has 20 years with the disease. The results would also be different.
Here is an example of HIV. When a person is infected with HIV, AIDS takes 10 years to appear. And during these years you go through different stages. After the acute infection, there is a latent clinical infection, with persistent swelling of the lymph nodes. Then it passes to the symptomatic stage where latent virus reactivations begin to appear, such as herpesvirus, fungal infections, diarrhea, weight loss, but not yet AIDS. This is the stage that resembles CFS/ME patients.
Then we move on to the AIDS stage, which is when CD4 lymphocytes start falling below 200 (it takes 10 years from when you become infected with HIV until you have AIDS).
That is, if we catch patients newly infected with the HIV virus and those who already have AIDS, the immunological results are different.
This is what we have seen in the analysis provided by the patients. Where patients who had been with the disease for more years had low levels of CD4 and CD8. But the patients who had been for a few years had these normal values and only low activated T lymphocytes. All of this is what we want to verify in the study and I would appreciate your help with fundraising and outreach. Because like you I am also sick and I want this to be verified as soon as possible. If our hypothesis is fulfilled we will have an acquired immunodeficiency diagnosis. This would allow us to seek specific treatment, such as what is currently being done to eliminate HIV.
With a little that each sick person, family or friends donate in a few days, the total could be collected.
Thank you very much in advance,
Greetings,
Manuel
Pd:If our hypothesis is confirmed we have another diagnostic method to confirm the results in another study.