There's an interesting article in the online-magazine CELL about a newly discovered hormone called IL-7 that is a claimed to be a very potent booster for the immunesystem...
www.cell.com
www.cell.com
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This is the company that makes the IL-7. I will write them and suggest they contact WPI. I already told WPI about them.
http://www.cytheris.com/Clinical_Trials/hiv.php
hi spacca. they are doing a trial to see if they can reduce reservoirs or eradicate HIV using IL-7:
http://clinicaltrials.gov/ct2/show/NCT01019551
not sure how they can do this until enough drugs reach the brain and gut...but who knows.
Nucleotides enhance the secretion of interleukin 7 from primary-cultured murine intestinal epithelial cells.
Murakami R, Yamada K, Nagafuchi S, Hachimura S, Takahashi T, Kaminogawa S, Totsuka M.
Department of Applied Biological Chemistry, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan.
Abstract
Our previous studies showed that dietary nucleotides fed to mice enhanced the secretion of interleukin 7 (IL-7) and transforming growth factor beta (TGF-beta) from intestinal epithelial cells (IECs). To explore whether nucleotides influence IECs directly to enhance the secretion of the cytokines or not, the effects of nucleotides added in vitro on the cytokine secretion from primary-cultured murine IECs were examined. When the mixture of nucleotide 5'-monophosphates (CMP, GMP, IMP, and UMP) or individual nucleotide 5'-monophosphates were added to the primary culture of IECs derived from BALB/c mice, the secretion of IL-7, but not that of TGF-beta, was increased significantly. Addition of nucleotides to the culture did not alter the number of the IECs. Secretion of IL-6 and granulocyte-macrophage colony-stimulating factor, which are known to be secreted from IECs, was not enhanced by the addition of nucleotides. These results demonstrate that nucleotides can affect IECs directly to enhance the secretion of IL-7, and suggest that the increased secretion of TGF-beta from IECs by dietary nucleotides was due to indirect effects of the nucleotides, which may affect intestinal microflora or cells other than IECs that in turn influence the cytokine secretion of IECs.
hi RR:
are there any US trials? i am xmrv+ and my c4 and c8 counts are lower than someone just about to die from aids....wonder if this company will look into trial some xmrv poz who have low c counts. were you able to speak to a real live person when you called?
thanks : )
Below are two articles on Dr. Pellegrini, an Australian boosting Interleukin 7 to rid the body of HIV and similar infections.
Rrrr,
Dr. Pellegrini's group switched off the SOCS-3 gene in their animal model. This technique appears to differ from the clinical trials that are administering IL-7 to HIV patients? Anyone comment?
http://www.wehi.edu.au/site/latest_news/boosting_bodys_immune_response_may_hold_key_to_hiv_cure
Rrrr,
Dr. Pellegrini's group switched off the SOCS-3 gene in their animal model. This technique appears to differ from the clinical trials that are administering IL-7 to HIV patients? Anyone comment?
http://www.wehi.edu.au/site/latest_news/boosting_bodys_immune_response_may_hold_key_to_hiv_cure
i thought it said that simply administering the IL-7 is what switched off the SOCS-3 gene, thereby allowing the body to naturally clear itself of virus. do i have that right?
On another thread someone from Australia said news reports indicated it would be a matter of years before those new drugs would be available. So I assumed maybe incorrectly Pellegrini's technique is different from just administering IL-7 which is being done now.