Even so after reading about cdr, assuming the theory isn't a load of crap and the treatments posited do actually work for ME. Then that might be the missing piece required to get the body in a consistent state or a cured state. As opposed to "a lot better but not 100%". Whilst I feel a lot better feeding my mitochondria and this often stops a crash dead in it's tracks. It doesn't cure me and nor would I think others if the underlying cause is not identified and resolved
There are a lot of people who believe in the theory. I first heard about Naviaux and CDR at Ben Lynch's SHEI conference, then heard him speak at the 2016 United Mitochondrial Disease Foundation Conference and then at the Stanford ME/CFS Symposium, where I recognized him before he spoke and was able to have a lengthy conversation with him about mTOR and this diagram from his CDR paper.
I told him what I was doing with my naturopathic/functional medicine care, which involved many of the columns in his chart. He very much approved and said that the key was to bring the body out of winter metabolism into summer metabolism after removing the cell dangers. That inspired me to do the n=1 experimenting I've done.
If my case we're as simple as just having herpes viruses do damage to my mitos, all would be easy. Maybe this approach would bring a cure to some of you.
However, I had damage from Cipro and 2 chemo drugs known to cause mitochondrial damage before the viruses rose up. I also had genetic iron overload missed by my doctors til the excess iron had caused Fenton reactions and hydroxyl radicals to damage my cells. And, I had chlamydia and mycoplasma pneumoniae that were finally eradicated by 4 months of IV antibiotics after oral antibiotics failed, which wiped out the oxalate degrading bacteria in my gut causing mito-damaging sharp oxalate crystals to form. And autoimmunity, triggered by the infections. I have been unwinding each of these issues, too, and maybe fully resolving each one, excepting the genetic iron overload, which needs to be optimally managed, will completely cure me.
I don't expect all of you will also gave all my issues, but having communicated with many of you,. I've learned that a great many of you have other complicating factors including heavy metals, mycotoxins, lipopolysaccharides, other gut issues, nutrient deficiencies/imbalances, collagen deficiency/structural issues, etc.
Unless all the cell dangers are dealt with, and the body's processes righted, it will be challenging to get better. One thing may have set off a cascade of other damaging events and imbalances. It's not so easy to put Pandora back into the box with a pill. I think if will take thoughtfully unwinding the damage that's been done and repairing what's gone awry to get to a cure.
I've dug into mitochondrial medicine, and there are too few doctors and must of them are only interested in helping little children with genetic mito diseases not die. It's rare that they'll see an adult patient. Even when they do, the tools they have are different than the rest of medicine - they use large doses of mito nutrients to help patients function better. There are mito and metabolism research groups, but they don't really see patients. No one is developing solutions for patients with acquired mito damage - it's a dream for the future as diabetes, cardiovascular, and Parkinson's and other neurodegenerative diseases are known to have damaged mitochondria. Where the most money is these days is in curing cancer - every known cancer has abnormal mitochondria. What we can learn from cancer research is amazing. There's also anti-aging research, which offered hope, too.
The attached paper is from some of these researchers. I was familiar with their previous, independent work, but pleased to see them finding each other and talking to each other, and think that learning from their combined work can help us.
