Hi Nikki,
Nobody retains these things long. If you got an injection for instance and it all absorbed in an instant, just as an illustration, 75% or so would be excreted in your urine. Fortunately 10 MCG of MeCbl is about all that can possibly be used in a day. One of the things about holding the sublingual for an hour or two is that it gives you a long relatively high serum level and enough absorbtion that the MeCbl is distributed throughout the body. A study a few years ago calculated that an oral dose of 125 mcg (absorbs about 10-11 mcg average) and is enough for the transcobalamin 2 is saturated becoming holotranscobalamin 2. With the 1000mcg sublingual, beyond that you get perhaps 100-200 mcg absorption and that is distributed throughout the body very quickly (except cerebral spinal fluid, and that is a different story) and reaches about 80% (my best estimate). of potential healing rate at the same time. My body would likely do fine on a 1000 mcg dose, but for some reason some people have a problem getting B12 into the brain or some lose it fast, or both. An injection of 10mg SC for me allows about 8-10 hours of CNS improvement. The body dose of 1000 mcg sublingual keeps things going for at least 24 hours and keeps deficiency symptoms from returning sooner than 3 days after the previous dose.
Methylfolate has a halflife of maybe 3 or 4 hours it appears. Depending upon how my body is working on a specific day I find that 15mg 2 to 4 times a day works well, and I can see the difference. When the methylation is working well, I don't see any MeCbl in my urine. When methylation isn't working well I see proportionately more b12. It appears that the folate can double or more the period of the serum half life of circulating MeCbl or circulating AdoCbl. Also, the folate symptoms are fast actors so that you can see the effects rapidly. I have angular cheilits at the corners of my mouth. The crack starts forming and burning feeling in 24-36 hours after going deficienct in the epithelial compartment. Also when very deficient the finger tips peel and crack deeper. The thumbs especially can have the cracks at the corner of the nails. A week ago I was working with cherries. They stained the cracks to be, DAY 2 of MeCbl deficiency. They were not cracks yet but the skin in the v-shaped crack to be was already dead and stained with cherry juice. I had started seeing b12 in my urine the day before, day 1 of deficiency, and having already been on 30mg, went to 60mg.. On day 3 the dead skin started coming of. Day 4 there was a 3mm wide crack and 3mm deep. On day 5 the crack was half as wide and half as deep. On day 6 the crack was all but filled with pink new skin and day 7 very faint remains can be seen if one knows what to look for, The angular cheilitis and finger cracks and peeling heal at the same rate. The burning feeling at the bottoms of the cracks starts within a day and stops a few hours after a large enough methylfolate dose. The only size I bother with these days 15mg. I keep the 800 mcg tablets around when I need them for other people and my cat; she gets only a tiny pinch of ground up pill. She gets 2 injections a week (300mcg). She had an inflammatory digestive disease and was losing weight and vomiting and really miserable. Since the vet suggested the MeCbl, it helped a little, but the folate. WOW She has gained perhaps 4 pounds and has gone in weeks from a young small cat to a noticeably larger more solid cat without a sore tummy and food intolerances requiring a "single protein" cast food at high price and she hates it.
It is obvious for me that many things can heal. What takes so long is when normal healing and replacement doesn't take place at the needed speed and that goes on continuously. I had missed out on decades of normal healing with degeneration for years. I lost 50 pounds of muscle atrophy from lack of b12 and folate. If you get.canker sores, burning tongue, mouth, sores down the throat, IBS, also acne type lesions, all sorts of rashes and so on. Hundreds of those can heal in a week or two of enough folate, and they will stay gone with enough methylfolate. I had them come and go learning this lesson hundreds of times before I got it. WHen you get rid of the IBS you will likely absorb much better. My partner had a real stomach pain, bleeding, and other problems. Without having all the external problems like me, without any extra potassium needed, she started on 4mg of methylfolate, and it helped a little but it came and went. at 15mg methylfolate it doesn't come back, and with a single 10mg injection a day of MeCbl because of neurological damage from neck injury and fusion. The doctor no longer wants an endoscopy done.
http://www.methylpro.com/ various sizes, ie 90 caps, 15mg $75.00 - works same for me. I do find that changing brand even for a day each few months makes a difference. That was one of the factors I was exploring.
On the LCF (AdoCbl really makes no difference, either you have enough or you don't) it is the one thing that you really can titrate. I started at 64 mg a day, and then 128, 256 and then 500mg a day. Starting at 500 was way too muchjfor me. If you stop and go it STOPS cell formation. Making this stop and go increases damage and reduceses healing,. It works best to get it going and keep it going. One of the things that happens is that it allows things to really heal. With the AdoCbl/LCF it promotes more mitochondria being made to restore exercise tolerance. LCF promotes neuroblasts, osteoblasts, helped heal my muscles and heart. It also helped repair my liver along with the methylfolate and losing 85 pounds of water from my abdomen.
Stop and start makes the swings crazy. It's best to get it stable. And everything smooths out. If one doesn't get enough methylfolate, it comes and goes and never quite heals.
I have another "slow clock" also that backs up my visual B12 in urine method. My MCV responds to haw many days a month I have effective methylation. Most of my life and with folic acid, my MCV was 99.8 or more. At 8mg a day my MCV went down to 98.?. At 15mg it went down to 95-97.? At 30mg it's down around 93-94.? When things get worse, symptoms wise, the MCV goes up. I can count the number of day of skin worsening or improving. and it matches with up or down on the MCV.
I take a 15mg at bedtime and again when I get up and 2 other times. If you feel the MeCbl wearing off, take one in the evening too. None of these EXCEPT LCF has a near linear response. I already described the response curve of methylfolate, MeCbl varies something like this, @ 10 mcg absorbed, 1% effective. 100mcg absorbed, 80% effective, 1000mcg absorbed 95% effective, 10,000 mcg absorbed, 99+%.effective. This again is my best approximation. I hope this clarifies things. If you are taking too much b1, b2, b3 and inositol, that will help right away.
Part of the problem with potassium is that if you take too much it cause irritation that reduces absorption. Too much at once makes more loss in the urine. I find taking potassium gluconate in water more effective, sipping it all day than taking huge doses by pills. Time release PILLS are dangerous. High dispersion multi time pill capsules are better and less damaging. Drinking low concentration water for all your water helps. The potassium in water can be absorbed in 15 minutes or a little more. Food potassium serum peaks 14 hours after consumption.