i just recently started taking high doses of methylfolate (16mg/day) and the first couple days in gave me a lot of mental energy but now I am EXHAUSTED. I have been sleeping over 12 hours a day and even after than I feel I could go back to bed. Is this healing taking place?
Also, the other day I felt like I couldn't catch my breath and think I had a panic attack and proceeded to fall asleep for 4 hours. This seems uncharacteristic of a normal panic attack. What could be going on here?
Hi Acrosstheveil,
This sounds to me like an induced deficiency. It might be AdoCbl and/or LCF Methylation puts a heavy demand on these. I remember noting at the time that I felt very tired and lethargic similar to how I felt after beating off a pneumonia with 104 fever; "convalescent" I called it at the time. That was before I knew a thing about induced deficiencies. Below are the folate and potassium common induced symptoms.
Death from B12 deficiency has been variously described as terminally fatigued or paralysis. Low potassium can also make muscle contractions near impossible. When the mitochondria goes off Krebs cycle and does anaerobic metabolism generating 1/6 the enrgy and lactiovc acid which makes for burning muscles. I had that for 17 years from a few days after I crashed until I took enough MeCbl (converts to AdoCbl to a degree). Good luck.
Version 1.2 12/08/2013
Group 1 – Hypokalemia onset. Symptoms may appear with serum potassium as high as 4.3. May become dangerous if ignored. Considered “rare” with CyCbl (Cyanocobalamin) it is very common with MeCbl (methylcobalamin) and AdoCbl (adenosylcobalamin) and less so with HyCbl (Hydroxycobalamin).
There does not appear to be a clear order of onset. The order of onset varies widely from person to person but many appear consistent for each episode for any given person. There tend to be more and more intense symptoms as it gets worse. Some people have ended up in the ER because of not recognizing the symptoms.
IBS – Steady constipation, Nausea, Vomiting, Paralyzed Ileum,
Hard knots of muscle, Sudden muscle spasms when relaxed, Sudden muscle spasms when stretching , Sudden muscle spasms when kneeling, Sudden muscle spasms when reaching , Sudden muscle spasms when turning upper body to side, Tightening of muscles, spasms and excruciating pain in neck muscles, waking up screaming in pain from muscle spasms in legs. Muscle weakness
Abnormal heart rhythms (dysrhythmias), increased pulse rate, increased blood pressure
Emotional changes and/or instability, dermal or sub-dermal Itching, and if not treated potentially paralysis and death.
Group 2a - Both
IBS – Diarrhea alternating with constipation, IBS – Normal alternating with constipation
Group 2b – Either or both
Headache, Increased malaise, Fatigue
Group 3 - Induced and/or Paradoxical Folate deficiency or insufficiency
These symptoms appear in 2 forms generally, the milder symptoms that start with partial methylation block and the more severe symptoms that come on as partial methylation block gets worse or very quickly with methyltrap onset.
Edema - An additional thing I would like to mention. I would never have found it without 5 years of watching the onset of paradoxical folate insufficiency and trying to catch it earlier and earlier and to figure out what was causing it and to reverse it. For me the onset order goes back to the day of onset now with edema and a sudden increase of weight. I noticed that within 2 hours of taking sufficient Metafolin I would have an increase in urine output.
Old symptoms returning
Edema
Angular Cheilitis, Canker sores,
Skin rashes, increased acne, Skin peeling around fingernails, Skin cracking and peeling at fingertips,
Increased hypersensitive responses, Runny nose, Increased allergies, Increased Multiple Chemical Sensitivities, Increased asthma, rapidly increasing Generalized inflammation in body, Increased Inflammation pain in muscles, Increased Inflammation pain in joints, Achy muscles, Flu like symptoms
IBS – Steady diarrhea, IBS – Diarrhea alternating with normal, Stomach ache, Uneasy digestive tract,
Coated tongue, Depression, Less sociable, Impaired planning and logic, Brain fog, Low energy, Light headedness, Sluggishness, Increase irritability, Heart palpitations,
Longer term, very serious
Loss of reflexes, Fevers, Forgetfulness, Confusion, Difficulty walking, Behavioral disorders, Dementia, Reduced sense of taste, bleeding easily
Group 4 - HyCbl onset, degraded MeCbl onset, MeCbl after photolytic breakdown onset.
Itchy bumps generally on scalp or face that develops to acne like lesions in a few days from start.
