HHV-6 researcher Dr Bhupesh Prusty also finds "something in the serum" of ME/CFS patients

[Snow Leopard]

https://twitter.com/i/web/status/1223242526188089344

It seems like he says factors. Though I'm not sure about what 'transferable factors' are.

Note that he said "on a path".

The "path" most likely involves a method for filtration into different components (separated by size and potentially other chemical means), a means of testing whether the components have any noteworthy effects on healthy cells and then using various means of characterisation to discover what the active factor(s) are (which could also involve more filtration).

Prusty's latest finding is that this mitochondrial-altering factor transmits via the blood serum, because when he added ME/CFS patients' serum to healthy cells, their mitochondria began to break up.

Mitochondrial fragmentation should not be assumed to be a negative adaptation, see:
"Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand."
https://www.ncbi.nlm.nih.gov/pubmed/29233845

Aside, this is the context of Prusty's "sncRNA-U14" research:
"HHV-6 encoded small non-coding RNAs define an intermediate and early stage in viral reactivation"
https://www.nature.com/articles/s41525-018-0064-5

 

[Hip]

Mitochondrial fragmentation should not be assumed to be a negative adaptation, see:
"Physiological Mitochondrial Fragmentation Is a Normal Cardiac Adaptation to Increased Energy Demand."
https://www.ncbi.nlm.nih.gov/pubmed/29233845

Very interesting.

 

[olegsel]

Brain tissue exhibited a significant inverse correlation for immunostaining between cytochrome c oxidase subunit 1 (CO1), a MtDNA encoded enzyme subunit, and HSV-1; with lower abundance for mitochondrial protein in regions where HSV-1 was abundant.
https://www.ncbi.nlm.nih.gov/pubmed/27457581

 

[babeng]

If anyone wants to support Dr. Prusty's work financially, you can give a donation to this fundraising campaign specifically set up to support his work. He is "on a perfect path" of identifying what causes the signal in our blood and the disruption of mitochondria;

https://www.gofundme.com/f/gofundme...d=neIM37S3CNNzJvgGlEXb7AUR5MZoAEn5GW+0W0zxYHU=

 

[Annikki]

I would not like to say; I've never come across this apoptosis-inducing factor before.

It probably isn't the same thing, but I'm curious to the nature of the chemical found in the study. My guess is the chemical in mitochondrial-altering factor will be unique to ME and will serve bio-marker for the illness. Finding a new biomarker for ME would be excellent, both in terms of legitimizing the illness and enabling an easy test for ME that can be done in a doctor's office.
This will go a long way in preventing the typical diagnostic delays in new ME cases. Thanks again for sharing this, I think it's important.

 

[lauluce]

the proof that covid19 put the world on hold is that this thread stopped completely, even now that Dr Prusty's estudy paper is out!

 

[Rufous McKinney]

the proof that covid19 put the world on hold is that this thread stopped completely, even now that Dr Prusty's estudy paper is out!

Need some functional brainiacks to: translate all this.

Comments from actual other ME experts without AGENDAS would be nice.

 

[JES]

the proof that covid19 put the world on hold is that this thread stopped completely, even now that Dr Prusty's estudy paper is out!

The latest paper is being discussed here.

 

[Iknovate]

Random thought.

All this serum talk made me think of my pregnancies where I would repeatedly have the thought, "my blood is poisoning me."