Fluge and Mella in 2016 showed that when myoblast cells (young muscle cells) from healthy people were exposed to the blood serum of ME/CFS patients, the cells developed energy metabolism abnormalities.
That suggested that there is "something in the serum" of ME/CFS patients which is amiss, because even when healthy cells come into contact ME/CFS patients' serum they develop energy metabolism issues.
Prof Ron Davis also found evidence that something in the serum is affecting ME/CFS patients cells (see this thread).
And Dr Karl Morten of the Morten Group Oxford found something in ME/CFS patients' blood serum which affected the cells' ability to absorb oxygen (see this article).
@Cort's latest blog from the NIH ME/CFS Conference II details the work of German HHV-6 researcher Dr Bhupesh Prusty, who is now the third scientist to find "something in the serum" in ME/CFS patients.
Dr Prusty's has previously found that HHV-6 reactivation in cells changes mitochondrial structure and function.
But intriguingly, Prusty's research suggests this not only happens in HHV-6-infected cells, but even in healthy cells by some unknown mechanism or factor that remotely alters the mitochondria in uninfected cells as well (some info here).
Prusty's latest finding is that this mitochondrial-altering factor transmits via the blood serum, because when he added ME/CFS patients' serum to healthy cells, their mitochondria began to break up.
And when he added to healthy cells the supernatant (liquid) taken from a HHV-6 infection in cell culture, this also caused the same changes in the mitochondria.
And then removing removing ME/CFS patients’ serum from the cells caused the mitochondria to return to a healthy state again.
Prusty is now attempting to isolate this mitochondrial inhibiting factor from the serum. He is using the exosomes that Maureen Hanson is examining in her NIH research center.
Some articles about Dr Prusty's work:
SMCI 2016 RAMSAY TEAM 5 RESEARCH UPDATE
HHV-6 MEDIATED MITOCHONDRIAL MODULATION AND ITS ASSOCIATION TO ME/CFS
That suggested that there is "something in the serum" of ME/CFS patients which is amiss, because even when healthy cells come into contact ME/CFS patients' serum they develop energy metabolism issues.
Prof Ron Davis also found evidence that something in the serum is affecting ME/CFS patients cells (see this thread).
And Dr Karl Morten of the Morten Group Oxford found something in ME/CFS patients' blood serum which affected the cells' ability to absorb oxygen (see this article).
@Cort's latest blog from the NIH ME/CFS Conference II details the work of German HHV-6 researcher Dr Bhupesh Prusty, who is now the third scientist to find "something in the serum" in ME/CFS patients.
Dr Prusty's has previously found that HHV-6 reactivation in cells changes mitochondrial structure and function.
But intriguingly, Prusty's research suggests this not only happens in HHV-6-infected cells, but even in healthy cells by some unknown mechanism or factor that remotely alters the mitochondria in uninfected cells as well (some info here).
Prusty's latest finding is that this mitochondrial-altering factor transmits via the blood serum, because when he added ME/CFS patients' serum to healthy cells, their mitochondria began to break up.
And when he added to healthy cells the supernatant (liquid) taken from a HHV-6 infection in cell culture, this also caused the same changes in the mitochondria.
And then removing removing ME/CFS patients’ serum from the cells caused the mitochondria to return to a healthy state again.
Prusty is now attempting to isolate this mitochondrial inhibiting factor from the serum. He is using the exosomes that Maureen Hanson is examining in her NIH research center.
Some articles about Dr Prusty's work:
SMCI 2016 RAMSAY TEAM 5 RESEARCH UPDATE
HHV-6 MEDIATED MITOCHONDRIAL MODULATION AND ITS ASSOCIATION TO ME/CFS
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