I wonder whether one under-appreciated issue related to cartilage destruction in craniocervical issues might be the role of glycine deficiency. Glycine is an amino acid that is essential for making or restoring cartilage. The average dietary intake of glycine is roughly 1.5-3 grams per day.[1] This is not enough for the body's needs, so the body makes its own glycine to make up for the inadequate dietary supply. However, the way that the body makes new glycine is tied to the folate cycle, which means that glycine production can be slowed down by anything that slows down the folate cycle, such as B12 deficiency.[2]
One publication meticulously calculated the average body's glycine production and the average body's need for glycine. This paper found that the average body makes about 2.5 grams of glycine per day, but that the body needs a total of about 15 grams of glycine per day to maintain the amount of cartilage we had in early adulthood.[3] Although this is only one paper, their results may be supported by the in vitro observation that higher amounts of glycine continue to stimulate large increases in collagen synthesis, as if the cells know that the current collagen level must be inadequate.[4] (cartilage is made of collagen)
References
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627940/#idm139934315659552title
[2] https://pubmed.ncbi.nlm.nih.gov/19179765/
[3] https://pubmed.ncbi.nlm.nih.gov/20093739/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6153947/
NB: This post was adapted from the following post:
https://forums.phoenixrising.me/threads/is-your-hypothalamus-up-the-creek.81181/page-2#post-2294627
Hi @Pyrrhus....I don't know how I miss this, but I did. Do you have me on your list of notifications? The problem could have been at my end, I don't know. Anyway, Pyrrhus, I honestly (& I mean honestly) don't have time to read another newsletter today....right now I'm focusing on books that also contain recent research, and I'm wondering if you could once again put the name of the glycine supplement you're taking? I'm at at an age when what's left of the body has to seriously be preserved (not that I haven't tried for the past 30++ years). Anyway....when you have a moment, it would be appreciated. Thanks, @Pyrrhus. Yours, Lenora.