Yes
@globalpilot , I was taking folinic -- but very sporadically this year -- and have paid the price. I have notes of ordering it nine times from November 2012 to December 2013, and was doing 'better' during that period, although I started to lose some weight around October of 2013 (mostly superficial belly fat).
My next order was late April 2014 -- and then early July -- and that's it. I attributed some extreme irritability to the folinic in late July, when it was probably due to a couple of different supplements that are high in choline, which in hindsight I don't think I tolerate well. And that could be because one needs sufficient b12 (and carnitine) for the enzyme that breaks down acetylcholine -- and I hadn't been taking b12 as well hardly at all this year.
During the last year I've lost a lot more muscle (and I'm extremely thin to begin with), so now I am almost housebound, and have to use a wheelchair to get my mail in the building -- a huge building. They have shuttles to take us to the grocery store, but I haven't been able to do that since about April or May…due to being so weak, losing more muscle. Plus, since about May or so, I developed an increasingly stuffy nose, and either dry or runny, goopy eyes. I've had the dry eyes off and on before (and the chronic sinus issue) but this has been a long, six-seven month ordeal, and just realized that methylation is one of the key ways that histamine is broken down, so will see if it helps. ???
It is indeed interesting that the dose of folinic is so high in that study.
Even higher than some with the auto-antibodies are reported using.
And no mention of b12 or potassium…
???
p.s. One thing I read the other day was that folinic has a half-life of 6-7 hours. And one person was finding that she needed to take it based on the half-life in order to find benefits. She also said it was her experience that the methylb12 made a difference as well. She started with the methylb12, but it wasn't until she took high doses of folinic, that she got better. Her doses varied over a period of a year, and eventually was able to lower them both, but in her case the had the auto-antibodies, and needed to cut out dairy in order to be able to lower her doses.