Hi adreno, under somewhat controlled conditions(not taking anything else right now) I still think I'm better. Not sure someone wants to research me to prove that, however.
Yes, but I don't know if you're better, only that you're telling me you are. And I don't know if I will be better, if I do the same as you.
Even if I believe that you're better, I don't know whether this is due to B2 (in this case), placebo, or some third unknown factor that happened to coincide.
I agree we do have to experiment. But I still like to have at least a plausible mechanism for why a suggested treatment might help. I wouldn't try a rife machine, for instance, because I don't believe in the underlying "theory".
That said, I'm currently trialing riboflavin also. I regard it as an easy and low risk treatment. As long as the theory is not falsified, and is at least plausible, I'll consider it. But if I find evidence, from a credible source, that the theory is invalid, I'll drop the treatment and try something else.
There has to be some way we select treatment modalities to try, and currently this is the priority I value them by:
1. Randomized, controlled trials.
2. Other studies, single case studies.
3. Clinical experience from credible doctors
4. Anecdotes
So far, for this B2 theory, we have only anecdotes, which is the least credible of evidence. This, of course, does not mean that the theory can't be right, it very well might turn out to be.
I'm not asking for research showing B2 will cure or improve CFS, that research doesn't exist. I'm just looking for evidence to validate the mechanism of B2 as proposed by Dog Person.
If her claims checks out, it strengthens the credibility of her theory. If not...well.
Same goes for Rich VanK. Do I have evidence that CFS is caused by a methylation block? No. But his theory sounds plausible, is logically coherent, the mechanism is possible and the facts he states are supported by evidence. That makes it a treatment worth trying, in my view.