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I take Niacin only in low doses because of severe adverse effects at a certain threshold. In the context of the IDO trap, I would recommend taking low doses of Niacin, Niacinamide, Nicotinamide riboside, or any other Niacin metabolite that helps to support the NAD+ buffer. But most importantly, and I often don't remember to mention this because I assume it's common knowledge, I take Coenzyme Q10.
There exist mRNA tests that can screen the whole range of metabolites at once. But not many laboratories offer this. I'm from Germany, so maybe someone else knows where to test this in the US. For instance, I found this US laboratory that offers something similar, though not complete. Just make sure that homocysteine is also tested if it isn't included. I think this is the most important marker. If you also have methionine, cysteine, SAH, or SAMe levels, this allows for better profiling of the methylation status.
This website explains the extended methylation cycle in simple terms. Regarding NAD, I'd refer to this Wikipedia article.
Is there any particular reason why you take creatine? For Q10, there is a blood test available as well.
I was taking creatine because Chris Masterjohn said that a lot of methylation goes into creating creatine so supplementing it frees up methyl groups. Since I wasn't doing well on folate and b12, taking creatine helped my histamine intolerance slightly.