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From very severe to moderate in two months

Hip

Hip

Senior Member
Messages
17,872
Martin aka paused||M.E. said:
Two months ago I was very severe for two and a half years. Now I'm back to moderate since starting my new treatment:

4mg Abilify+4.5mg LDN+100mg Celebrex.

It's an anti-inflammatory treatment
Prescription by GP
Click to expand...

That's great!

Did you ever try any of these treatments individually before? Like LDN for example? Just wondering if your improvement is due to just one of these drugs, like Abilify, or more than one?

Very few ME/CFS patients get major improvements from LDN (only around 3% of patients, according to this poll). So seems unlikely that LDN made this major improvement you achieved. There could of course be some synergistic effects.
 
Martin aka paused||M.E.

Martin aka paused||M.E.

Senior Member
Messages
2,291
Hip said:
That's great!

Did you ever try any of these treatments individually before? Like LDN for example? Just wondering if your improvement is due to just one of these drugs, like Abilify, or more than one?

Very few ME/CFS patients get major improvements from LDN (only around 3% of patients, according to this poll). So seems unlikely that LDN made this major improvement you achieved. There could of course be some synergistic effects.
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Yes I tried LDN alone and it didn’t make a difference while Abilify alone did. But the major improvement came when I added LDN and Celebrex
 
C

choochoo

Senior Member
Messages
130
I agree with Hip. As far as I'm concerned LDN is a waste of time. Efficacy of this treatment is thin on the ground. In other words a waste of time.
 
Last edited:
Hip

Hip

Senior Member
Messages
17,872
choochoo said:
I agree with Hip. As far as I'm concerned LDN is a waste of time.
Click to expand...

I would not say LDN is a waste of time. When LDN works well for a patient, it can make a major difference. It's just that it does not work very often. But given how cheap and safe it is, it's one of the treatments worthwhile trying, just in case you do respond to it.

This is actually the story with most ME/CFS treatments: they tend only to make a major difference in a small subset of patients. This is why finding something that helps your ME/CFS is a case of testing out various treatments, in the hope of finding the treatment which works for you.
 
B

bthompsonjr1993

Senior Member
Messages
176
choochoo said:
I agree with Hip. As far as I'm concerned LDN is a waste of time. Efficacy of this treatment is thin on the ground. In other words a waste of time.
Click to expand...

LDN for just a few weeks took me from mild all the way to severe. After stopping it it took me two months to get from severe to moderate. But I have never been able to get back to mild. That drug did a lot of bad for me.
 
Wayne

Wayne

Senior Member
Messages
4,308
Location
Ashland, Oregon
IThinkImTurningJapanese said:
Few Doctors seem to be knowledgeable about silymarin.
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I buy milk thistle seeds in bulk, which apparently contain about 70% silymarin. A pound costs about $17 or so on Amazon. Here's a blurb on milk thistle [from THIS ARTICLE]:

Milk Thistle
Milk thistle, or Silybum marianum, is the richest source of silymarin. In fact, silymarin is often called milk thistle extract because its seeds contain about 70 percent of the phytonutrient according to the “Encyclopedia of Natural Medicine." Other parts of the milk thistle plant, such as the sprouts and stems, also contain silymarin, but the seeds are the most concentrated form
 
Hip

Hip

Senior Member
Messages
17,872
bctjr1993 said:
LDN for just a few weeks took me from mild all the way to severe. After stopping it it took me two months to get from severe to moderate. But I have never been able to get back to mild. That drug did a lot of bad for me.
Click to expand...

Wow, that's a pretty bad outcome from LDN. I've not come across such a major adverse effect like that before. A lot of patients find LDN hard to tolerate at first, and it makes them worse, so they have to reduce the dose to a tiny fraction of the normal dose, and then proceed very slowly to increase it. But I can't remember coming across a result as bad as you experienced.
 
HABS93

HABS93

Senior Member
Messages
485
Is LDN worth trying ? My problem isore neurological symptoms that I can't find anything that helps with them. Even the 1500mg of NAC after two months felt no different. Weed causes my neurological symptoms to be worse so it's something is wrong with my nervous system? Also explains the tingly feeling I get when I'm moving . Comes and go.
 
Y

Yuno

Senior Member
Messages
118
choochoo said:
Martin

I have ordered some abilify ( several days ago ). May I add, what dose of abilify did you start on? Or did you go straight to 4.0mg?
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hi,

could i ask where you ordered your abilify? are there trustworthy online resources?
 
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