From very severe to moderate in two months

[Hip]

Two months ago I was very severe for two and a half years. Now I'm back to moderate since starting my new treatment:

4mg Abilify+4.5mg LDN+100mg Celebrex.

It's an anti-inflammatory treatment
Prescription by GP

That's great!

Did you ever try any of these treatments individually before? Like LDN for example? Just wondering if your improvement is due to just one of these drugs, like Abilify, or more than one?

Very few ME/CFS patients get major improvements from LDN (only around 3% of patients, according to this poll). So seems unlikely that LDN made this major improvement you achieved. There could of course be some synergistic effects.

 

[Martin aka paused||M.E.]

That's great!

Did you ever try any of these treatments individually before? Like LDN for example? Just wondering if your improvement is due to just one of these drugs, like Abilify, or more than one?

Very few ME/CFS patients get major improvements from LDN (only around 3% of patients, according to this poll). So seems unlikely that LDN made this major improvement you achieved. There could of course be some synergistic effects.

Yes I tried LDN alone and it didn’t make a difference while Abilify alone did. But the major improvement came when I added LDN and Celebrex

 

[Mary]

@Martin aka paused||M.E. - this is huge, I'm so glad for you - thanks for letting us know!

 

[choochoo]

I agree with Hip. As far as I'm concerned LDN is a waste of time. Efficacy of this treatment is thin on the ground. In other words a waste of time.

 

[Hip]

I agree with Hip. As far as I'm concerned LDN is a waste of time.

I would not say LDN is a waste of time. When LDN works well for a patient, it can make a major difference. It's just that it does not work very often. But given how cheap and safe it is, it's one of the treatments worthwhile trying, just in case you do respond to it.

This is actually the story with most ME/CFS treatments: they tend only to make a major difference in a small subset of patients. This is why finding something that helps your ME/CFS is a case of testing out various treatments, in the hope of finding the treatment which works for you.

 

[bthompsonjr1993]

I agree with Hip. As far as I'm concerned LDN is a waste of time. Efficacy of this treatment is thin on the ground. In other words a waste of time.

LDN for just a few weeks took me from mild all the way to severe. After stopping it it took me two months to get from severe to moderate. But I have never been able to get back to mild. That drug did a lot of bad for me.

 

[Wayne]

Few Doctors seem to be knowledgeable about silymarin.

I buy milk thistle seeds in bulk, which apparently contain about 70% silymarin. A pound costs about $17 or so on Amazon. Here's a blurb on milk thistle [from THIS ARTICLE]:

Milk Thistle
Milk thistle, or Silybum marianum, is the richest source of silymarin. In fact, silymarin is often called milk thistle extract because its seeds contain about 70 percent of the phytonutrient according to the “Encyclopedia of Natural Medicine." Other parts of the milk thistle plant, such as the sprouts and stems, also contain silymarin, but the seeds are the most concentrated form

 

[Hip]

LDN for just a few weeks took me from mild all the way to severe. After stopping it it took me two months to get from severe to moderate. But I have never been able to get back to mild. That drug did a lot of bad for me.

Wow, that's a pretty bad outcome from LDN. I've not come across such a major adverse effect like that before. A lot of patients find LDN hard to tolerate at first, and it makes them worse, so they have to reduce the dose to a tiny fraction of the normal dose, and then proceed very slowly to increase it. But I can't remember coming across a result as bad as you experienced.

 

[bthompsonjr1993]

@Hip Yeah taking that medicine is my single biggest regret in the 6 years I’ve had CFS

 

[Mel.issa]

I also take abilify I'm also in the UK my doctor was unwilling to prescribe it as he told me that only psychiatrists can prescribe so I ordered it from an online pharmacy.

@Jessie 107 can you share which pharmacy you ordered from I am also in the UK with a very blinkered GP

 

[Jessie 107]

@ Mel.issa
Cheapmedicineshop.com also you can use PayPal. But not officially use PayPal...talk to the chat box and they will explain how to pay.
The generic name is Asprito.

 

[HABS93]

Is LDN worth trying ? My problem isore neurological symptoms that I can't find anything that helps with them. Even the 1500mg of NAC after two months felt no different. Weed causes my neurological symptoms to be worse so it's something is wrong with my nervous system? Also explains the tingly feeling I get when I'm moving . Comes and go.

 

[mitoMAN]

Wondering why you only take 100mg Celebrex?


Do you have huge IL-1B spikes?
I was planning to use it for surpressing my Interleukin 1 Beta sideffects.
Studies propose 600-800mg effectively.

See:
https://www.ors.org/Transactions/50/0942.pdf

 

[mitoMAN]

Several scientific papers suggest Abilify has potent anti-viral s well as anti-inflammatory properties.

Do you happen to know if this is unique for Abilify or also matches other atypical antipsychotic like Quetiapine. (which i take for sleeping aid)

 

[Yuno]

Martin

I have ordered some abilify ( several days ago ). May I add, what dose of abilify did you start on? Or did you go straight to 4.0mg?

hi,

could i ask where you ordered your abilify? are there trustworthy online resources?

 

[Treeman]

Cheapmedicineshop.com also you can use PayPal. But not officially use PayPal...talk to the chat box and they will explain how to pay.
The generic name is Asprito.

could i ask where you ordered your abilify? are there trustworthy online resources?

 

[Yuno]

thanks!

 

[Strawberry]

Martin this the best news I’ve heard in a while. So happy for you! Hope you can improve more.

 

[Timaca]

Thanks for sharing. Please continue to share your experience. I wish you continued and fast improvement to total wellness!

 

[Martin aka paused||M.E.]

Do you happen to know if this is unique for Abilify or also matches other atypical antipsychotic like Quetiapine. (which i take for sleeping aid)

I don’t Know. I only know it from Stanford, tried it and after a week I was from very severe to severe