Wow, that's quite a story,
@Iquitos.
You do occasionally hear of remissions from ME/CFS, though, when taking ayahuasca or dimethyltryptamine (DMT). DMT is of course the main psychedelic ingredient in ayahuasca.
For example, see
this account of an ME/CFS patient who took 3 ayahuasca trips on different occasions, and each time he said he had 100% remission from ME/CFS and all its symptoms for the duration of the ayahuasca trips.
And there is
this account of someone who had ME/CFS for 6 years, but says he was cured after just
one dose of pure smoked DMT (but he only posted follow up comments for around a month).
Could DMT have precipitated viral clearance in his body?
DMT interacts with a number of receptors: DMT affects eight types of serotonin receptor, as well as the dopamine D1 receptor, the alpha 1 and 2 adrenergic receptors, the sigma-1 receptor, and others. Ref:
here.
I found
this interesting paper, which said that higher peripheral serotonin levels are linked to better outcomes from antiviral treatment for hepatitis C virus. So might the activation of serotonin receptors by DMT have some kind of antiviral effect, leading to a remission from ME/CFS?
DMT Sources
Some people extract DMT from plants that contain it like
Psychotria viridis or
Mimosa hostilis, and then smoke this DMT. By smoking DMT, you bypass the MAO enzyme in the stomach which breaks down DMT, so you don't need to use an MAO inhibitor as you do with ayahuasca (the ayahuasca brew contains potent MAO inhibitors which come from the Banisteriopsis caapi plant to prevent DMT breakdown). And when smoking pure DMT, I understand there is rarely any vomiting.
Trouble is, I have read that pure DMT trips, fascinating as they sound, are in many respects more intensely psychedelic than even LSD, so people like myself with psychiatric comorbidities to their ME/CFS (namely anxiety, anhedonia, emotional flatness, and occasionally some mild psychosis) might be at risk of precipitating psychosis from DMT.
Although I wouldn't mind trying micro-doses of DMT (doses too small to produce a major psychedelic effect), to see if that would help with any ME/CFS symptoms. DMT is illegal in most countries, but the plants that contain DMT are not, and there are various
DMT extraction recipes on the internet. There is a thread
here about low dose DMT (apparently there is no tolerance build up), but I was thinking of even smaller micro-doses of DMT.
I did some micro-dosing of the legal psychedelic herb
Tabernanthe iboga a few years ago, to see if it would help my anhedonia and emotional flatness (blunted affect) — the iboga trip is a profoundly emotional one, so this is why I though it might help treat emotional flatness — but I did not notice any major improvement, though it helped a bit. Also increased my general conscious awareness for several days after. Iboga is the herb that can completely cure alcohol or heroin addiction in just one session. Iboga appears to reset the brain's tolerance of and addiction to a substance.