Another report (from Reddit user
Arpeggio_Miette) of kambo placing an ME/CFS patient into remission for a few days, after which they slowly start getting worse again, and return to baseline:
Kambo is the # 1 thing (along with Valtrex and SAM-e) that has helped my ME/CFS. Each time I do it, I feel like I am in remission for a couple days, then I slowly get worse and go back to how I was before. Except, not as bad. My baseline is slightly higher than before.
And this happens almost every time I do Kambo (some don’t seem to help as much, and the Kambo session where I fainted and hit my head and got a mild concussion understandably made me worse due to the concussion). So my baseline has been slowly going up as I do more Kambo treatments (and I am careful to not get up if I feel like I might faint).
No, Kambo is NOT fun. I would say that for 1/4 of my sessions, I am beyond miserable, lying down completely weak and in extremely horrible unbearable discomfort, crying for my late mom and begging for it to stop. Luckily, that is not the usual experience, in which the extreme discomfort is bearable and only lasts maybe 5 or 10 minutes.
But it has helped me so much, that I am planning to become trained to self-administer the medicine so that I can have more frequent and more affordable treatments.
The difference in my abilities a year and a half ago (when I had my first Kambo session) and now (after 12 Kambo treatments) is huge. And it really helped my POTS; I was dependent on low-dose propranolol to manage my POTS before Kambo. Now I rarely ever take the propranolol; I no longer need it.
As you can see, Arpeggio_Miette did not enjoy the kambo sessions!
But note that you can try daily kambo microdosing instead of taking the full dose. I believe Jox evetually switched to microdosing (Jox is the person whose ME/CFS remissions via kambo I reported in this thread).
I actually tried some microdose sessions with a kambo stick I bought. I took 1 mg of kambo powder intranasally (took some kambo from the stick and crushed into a powder, then snorted).
Snorting kambo is NOT recommended though, as there can be an infectious pathogen present in kambo, which can cause an incurable heart and brain illness called the "frog's disease" (detailed in
this post). However, at the time, I was not aware of the frog's disease.
If it were not for the frog's disease risk, snorting kambo would be a viable mode of administration (much better than getting permanent scars via the skin burn method).
I was looking into trying to sterilise a kambo stick by sending it away to be gamma irradiated. Then it should be safe to snort kambo powder. But unfortunately I could not find a gamma irradiation service open to the public.
Here is my report from my 1 mg snorting sesssion, which I did in 2012:
Intranasal 1 mg kambo has a very fast acting effect: I went bright red as blood rushed to my skin (a bit like a niacin flush), and there was some increase in heart rate, plus a very, very slight feeling of nausea, and some intestinal rumblings, but nowhere near actually physically getting sick, only the mildest hint of it.
The whole thing lasted less than 5 minutes.
No mental state changes occurred at all during this experience: I remained calm, focused and mentally the same throughout. So there are no psychoactive effects to kambo.
I did not notice any improvements to my ME/CFS from this microdose session, but maybe you would have to do a week or so of daily microdosing to get benefits.