Since Sueami brought up my name, I thought I'd give an update on my use of transdermal B12 oil. I've been using one daily pump dose of the mB12/aB12 combo since April 2013. I had a GPL OAT In June 2013 and another in December 2014. Both tests showed my MMA to be right around the midway mark. I also have had very recent bioscan testing, and it showed that I had sufficient B12 in me. So I believe it's working for me. I have a number of homozygous and heterozygous MTHFR mutations, including homo A1298C and many others, but not C677T. I have 2 MTRR heterozygous mutations. I do not have CFS, but was definitely low energy.
Here is some of my history, to put my transdermal B12 experience in perspective. I had previously tested low in B12 in 2008, on a Spectracell Micronutrient test. B12 was the only specific nutrient I tested deficient in, in addition to being deficient in total antioxidant function, but not any of the individual antioxidants. According to Rich, my low total antioxidant level could be explained by my +/+ GSTP1. So my diet and supplement regime, despite being good and with ample meat in it, still left me deficient in B12.
After my 2008 test results, I started using daily sublingual B12, letting it quickly disappear under my tongue. I started taking Jarrow sublingual B12 and adenosylB12 (Country LIfe?) in summer 2012, using Freddd's technique of parking the lozenge between my upper gum and cheek. During that period, I had no testing of my B12 levels. However, when I went to the dentist in October 2014, I was told I needed inlays on 5 molar teeth because of erosion of the enamel around previously placed resin fillings. I hadn't had any new cavities in the 11 years prior to that, and that was only one cavity. I attribute the new decay to having the acid-based sublingual B12 in contact with my teeth for 45 minutes every day, because it felt like it was etching my teeth.
Someone asked about light damage occurring with the transdermal B12 oil. I don't see how any light could reach the B12 oil while it is in the pump, because the contents are shielded by a silver coating on the outside of the pump. Once you pump it out onto the skin, it takes maybe 10-15 seconds to rub it into the skin. That would be the only exposure to light. Since their animal tests are showing good results, it doesn't seem likely that any degradation occurs in that very brief period. As I understand it, the B12 molecules are nano-sized and embedded in the oil solution, so I would think that would also serve to protect the B12 from light degradation.
I order 6 pumps from B12oils.com at a time, and at this quantity, the per pump cost, including shipping to Nebraska, is $42. Each pump lasts me around 2 months. I have been assured that the B12 oil will still be potent by the time I'm using that sixth pump. And the transdermal oil B12 is a heck of a lot cheaper than bills for dental restoration.
For those of you needing high doses of B12, you might need to check your Vitamin B2 levels. Vitamin B2 is needed as a cofactor for metabolizing B12.
