In me, the choline helped against poor gastric and small intestinal motility (food staying in the stomach and then emptying at night, giving me poor or no sleep like a person who has eaten far too much before going to bed...). But I do not know if it helps against any colonic motility issues, that is, constipation. Neurotransmitter-wise constipation is about
low gaba or
high NO or
low serotnin. I do not know, if acetylcholine is involved or not in motility of the colon. If you find publications on google scholar, pls post, many people will want to learn about this.
What I do know:
Constipation is about
low potassium ,
gram-negative bugs ,
neuropathy or
loss of glial cells. Then, one needs to differentiate between different forms of constipation. Did you get tested if transit is slow? Or do you have outlet constipation? The latter can be simply a bad habit of
how to use the muscles.
I just posted these from old note I have taken long times ago when I did have the problem. Today I do not. Practically, what I recall what helped: Lots of veggies. I do tolerate raw veggies best, but not everyone does. And, if I happen to need to go to the toilet, dont postpone it for doing something else first. Go asap. This has to do sthg with habit. And, squat. There are fancy things such as squatty potty you can buy, Or one can simply squat beneath the toilet and when it comes, then sit up quickly on it.

Running has a great effect and sometimes an immediate effect some 10 min later increasing likelyhood of a bowel movement. Then, there is the herb absynth (artemisia), the leaves of which are incredibly bitter (I love it!!

) and it has a similar effect to running.
In me, carbs cause constipation. I would probably test high on a methane breath test. I eat low carb, so I dont have constipation.
Back to the choline: I simply increased the dosage slowly up and down till I found the optimum. This is very different in people, some need a total intake of 500mg of choline per day, some 800 (food + supplements).
Wish you good success
