Hi guys!
Sorry for being absent for so long!!
Both. It was a complicated and multifacetted process. Many years ago, I had some small seemingly irrelevant flu-like infection. After that a very slow progressive decrease in health started. First, I had to lay down for a minute after lunch. This then increased and increased over the years till it became massive fatigue and hours of time loss. Adding to that: brain fog, more and more back pain, intolerance of any meat, etc etc. Then I tried to help myself in variousest ways, some more and some less successful. I also tried probiotics and killing intestinal bugs. This then catapulted me into a full-blown ME acutely.
- this is the super short version
I never tried parasym plus, so to say it cleary, I cannot give any answer based on own experience. But the dangerousthing in parasym plus is, as you mention it, the cholinesterase inhibitor. What I did, before even thinking of taking anything like that: measure my levels of cholinesterase. It is a simple blood test any better lab can do. My cholinesterase was at the lower normal limit. With that in mind , it looked to me very implausible that I could be a candidate for profiting from a cholinesterase inhibitor. Also Iread all the many reports on cholinesterase inhibition or parasym plus on PR. Such as this one:
http://forums.phoenixrising.me/index.php?threads/acetylcholine-caused-crash.43104/
So, so many people talking about damage and damage and damage!
--> While I cannot ynswer your question as to why the effect takes so long, I wonder why you take it at all? Why dont you try this: try the components individually, starting with the harmless ones, testing each for a few days before adding in the next. One could make a doctoral thesis about pharmacology of parasym plus.... testing the components individually delivers practical benefit in a simple way: more often than not, testing ingresients individually shows which is the ingredient that brings the positive effect and which one is the bad. I use this with all things: All vitamins, all minerals, everything. I am extremely sensitive, all multivitamins would case situations as you describe : some benefit, much harm. Trying them individually singled out a few things with benefit that really was unbelievable: resolving longstanding hopeless issues.
Essentially, what I do is:
- take everything transdermally to avoid feeding bad bugs.they love individual nutrients. choline is eaten to 60% by intestinal bacteria !! (see earlier posts on this thread for a reference)
- if there is an rdv for the substance, try some 50% rdv first and then slowly titrate upwards or downwards from there
- only one experiment at a time
- spend the time needed to read papers on google scholar and posts here on PR so I know what type of chynges to look for in what time frame. While this costs time, it is well-invested time.