Sterile inflammation due to mast cell activation is a possible explanation, I would guess.
Nanoung, despite I will keep trying with Mastocytosis, as I told you, I spoke on the phone with Dr.Escribano from Spain, one of the world's leading doctors in Mastocytosis who runs one of the best Mastocytosis Units in the world near Madrid. He told me that my symptoms could be Mastocytosis but I had to go there. Since I can't go anywhere outside the city and an affordable taxi distance I sent all my tests and medical reports to them. The doctor who reviewed them said that 100% sure that I don't have it. I spoke with her on the phone and insisted if they could be wrong and if they could at least test me for tryptase, which she refused but offered to speak with my Internist and suggest her to prescribe me oral chromoglicate, but I didn't do it.
Still, last week I got a prescription for a tryptase test from another Internist and I will do it sooner or later. I am not in a hurry and I am currently recovering from the extraction of my teeth with much pain in the sinuses area, but I will do it just in case.
Next week I also have an appointment with the neurolohist who suggested me I could have Mastocytosis in the first place. I had read about it extensively in the past and it was one of the diseases I had considered, but he made me go deeper. I will discuss with him these news on Ketiotifen and so on.
I am also a member of the Mastocytosis Canada forum and read there from time to time. Also in the Dysautonomia forums where some people reported improvement in POTS and Dysautonomia by treating Mastocytosis.
Last week I started to take a pill of 10 mg of loratadine every day, which didn't help, but after 3 days I stopped because I had my dental extractions and didn't want to mix too many medications, as I had to take antibiotics (doxycyline), antiinflammatories and pain killers, but I will try again with loratadine.
So, as you can see, I am interested in Mastocytosis and working on it, despite having being told by that very expert from the Mastocytosis Unit that I don't have it.
This is Dr.Escribano's Unit. The Institute for the Study of Mastocytosis, near Madrid. http://mastocitosis.org/
If you want to contact him, I'm sure he will talk to you on the phone to answer any doubts, He was very kind to me.