At least in my case. Unlike probably most here, I was fortunate enough to find out what was making me sick. To make a long story v short, i had a bone abscess in my jaw around my last molar. The abscess burnt itself out, but my body didn't conquer the infection. The bone had actually died died. X-ray didn't show this, I found it a few years later with a special type of ultra sound. Scan here -> http://i126.photobucket.com/albums/p95/dukeeeey/dental stuff/Image-Copy.jpg I've had surgery twice now to rid myself of this. And it still seems I have a bone infection there because it showed up on MRI -> But this is diverging somewhat. I knew the anaerobic bacteria in the dead bone were making me sick. When doctors or dentists look for problems, they look for all the usual signs of infection, raised temperature, white blood cell count, inflammation. But with a dry gangrene infection, which is literally what this is, you get none of those things. So the problem gets missed. I never even got pain in the area. Anyway during my research on gangrene, I found this http://en.wikipedia.org/wiki/Hydrogen_sulfide#Toxicity I am thinking, wow that sounds very much like it could cause CFS. DrMyhill in some of her lectures went on about the fact CFS patients are severely deficient in energy. She actually has a test where you can measure how bad it is, and they can tell you how much CFS you have. Jawbone cavitations produce exactly this kind of problem, with the anaerobic bacteria produce hydrogen sulphide. So then i searched for hydrogen sulphide and CFS, and wow theres a tonne of articles and papers on it. http://chronicfatigue.about.com/b/2...ome-breakthrough-what-is-hydrogen-sulfide.htm http://www.cfids-cab.org/MESA/Lemle.pdf But what all of these papers totally fail to explain is, where on earth would CFS patients be getting hydrogen sulphide from, if not from a gangrene infection, and CFS patients have no obvious rotting fingers and toes like someone who was frostbitten or something. The answer is obvious, from dental infections in the jaw, or simply root canal teeth. Not to mention all the other damage the metabolic waste the anaerobic bacteria cause, plus the acidity from the infections, but that's another point entirely. The problem is, even though I have scans and pictures of my jawbone problem. Doctors and dentists aren't taught the condition exists. And because it rarely if ever shows up on x-ray it never gets found. Thus in my case I ended up in the wasteland which is the mysterious CFS. I wouldn't say this is the only cause of CFS, i know people get can sick from toxic heavy metals place in their mouths (amalgams), but to me this seems like the most plausible theory I've ever read Here is a scan from the leaflet that originally found my problem Sadly quackwatch bankrupted the company with bogus lawsuits and it no longer exists .. but all is not lost because you can find bone defects with the right settings on MRI. Anyone any better theories ? Or we still stuck with it's a virus and drugs are the answer.