Elastase 2 Inhibitors

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Hi,

I hope this message finds you well.

I have saw this presentation it seems a good hypothesis who emphasizes on the pragmatic part:

Anyone tried Elastase 2 inhibitors Indole-3-Carbinol ? Horse Chestnut Seed Extract ? Streptochlorin ?

If yes in what dosages ? or what are the dosages from the presentation ?

Looking forward for your reply's.

Kind regards,
Nasaud
 

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I have not tried yet, but I have been thinking about it. My collagen changes need to stop.

I found two of those supplements easily. Indole-3-carbinol seems to normally be for women and work with estrogen. I’m a man so a little unsure about it and I don’t have the knowledge to decide if it would still work.
Streptochlorin seems harder to find.
 

Hip

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I have saw this presentation it seems a good hypothesis who emphasizes on the pragmatic part:
Would you know the timecode in the video where he explains the hypothesis, and details the elastase 2 inhibitors?
 

Hip

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Note that at 34:20 Dr Maxwell says he puts EDS patients on these elastase 2 inhibitors, but says he does not yet have any data to show that these alter the course of their illness.

I wonder if Dr Maxwell has any specific reason for thinking elastase 2 (also called neutrophil elastase) might worsen EDS. I did a quick search online, but could not find any info on this.

Previously in this post I speculated whether inhibitors of MMP enzymes (which also degrade connective tissue) might be useful in craniocervical instability.
 
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Note that at 34:20 Dr Maxwell says he puts EDS patients on these elastase 2 inhibitors, but says he does not yet have any data to show that these alter the course of their illness.

I wonder if Dr Maxwell has any specific reason for thinking elastase 2 (also called neutrophil elastase) might worsen EDS. I did a quick search online, but could not find any info on this.

Previously in this post I speculated whether inhibitors of MMP enzymes (which also degrade connective tissue) might be useful in craniocervical instability.
I have messaged he's clinic and him on linkedin if I have a answer from him I will post it here.

He has this presentation on the clinic's website:

https://heartofthevalley.us/docs/background
 
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Hi everyone, Doctor Andrew J. Maxwell, gave me a answer see it bellow:

"Hi *******, Sorry for the delayed reply. I need to make it very clear that these strategies are completely theoretical. I have been administering these supplements to my hEDS patients but do not have any evidence at this time that they are useful. In any case, I recommend these: Horse Chestnut Seed Extract Metagenics https://nhh.nutridyn.com/venaplexr VenaPlex Rutin 400mg Horse Chestnut Seed Extract 250mg (50mg aescins) Arjuna 100mg Take 1 tablet two or three times daily Indole-3-carbinol Metagenics https://nutridyn.com/meta-i-3-cr-1892 Meta I 3 C Stabilized Indole-3-Carbinol Take 1 tablet two or three times daily If you pursue these, let me know how it goes."

Kind regards,
Nasaud
 
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Hi everyone, Doctor Andrew J. Maxwell, gave me a answer see it bellow:

"Hi *******, Sorry for the delayed reply. I need to make it very clear that these strategies are completely theoretical. I have been administering these supplements to my hEDS patients but do not have any evidence at this time that they are useful. In any case, I recommend these: Horse Chestnut Seed Extract Metagenics https://nhh.nutridyn.com/venaplexr VenaPlex Rutin 400mg Horse Chestnut Seed Extract 250mg (50mg aescins) Arjuna 100mg Take 1 tablet two or three times daily Indole-3-carbinol Metagenics https://nutridyn.com/meta-i-3-cr-1892 Meta I 3 C Stabilized Indole-3-Carbinol Take 1 tablet two or three times daily If you pursue these, let me know how it goes."

Kind regards,
Nasaud
Were these supplements helpful to you @Nasaud ?
 
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Hi,

I cannot answer that question barely started them about 2 weeks ago, I am doing also pulse dose antibiotics I do not have hEDS. I have obtained hypermobility due to unknown factors, saw a connective tissue disorder specialist who told me that in my case not having a mendelian complex disorder I may try anything that has empirical value, that is the most pragmatic thing I can do for myself.

Kind regards,
Nasaud
 
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, I am doing also pulse dose antibiotics I do not have hEDS. I have obtained hypermobility due to unknown factors, saw a connective tissue disorder specialist who
thank you for posting this, fascinating.

I'm not hypermobile, either, but weakning of connective tissue and collagen seemed to have occurred.

Alot of the intense dysautonomic symptoms I was getting when I got much worse for a period of about three months which then required about a year to climb back to the place I was at prior to "the worsening".

What a brilliant doctor, wish I could see him.