Dr. Jay Goldstein said:
I no longer seek to improve the patient's condition; I expect to make him or her feel virtually normal, and I often can, except for perhaps 2 to 3 percent of the cases. My job is usually not very difficult. Sometimes patients feel dramatically better in ten seconds. Other times it can take several days or longer.
That remark by Dr Goldstein sounds more like exaggerated sales talk rather than sober scientific statement.
Well, it's certainly not a humble statement, that's for sure. Dr. Goldstein was not humble about his work, as a simple reading of his books (especially the first section of
Tuning the Brain) will show. Everyone describes him as a very kind, compassionate, and caring doctor. But his lack of humility is quite apparent in his own accounts, and this seems to be one of the things that cost him dearly in the community of CFS professionals.
However, if one is to be scientific about this, the accuracy of the quote cannot be determined simply by its content. So we look further...
Let's think about this. Dr Goldstein appears to be claiming here that he can make all but 2% or 3% of ME/CFS patients almost fully well. Now assuming this is a long term improvement he achieved (because if it were for just a few days or weeks, it would not be worth much), then Goldstein is saying he has devised the techniques to place nearly every ME/CFS patient into near full remission on a long term basis.
Yes, that appears to be exactly what he is saying, and that is how I've always interpreted this and similar quotes.
Now there are 17 million ME/CFS patients in the world, their lives in misery, costing billions to the economy and to insurance companies, and yet Goldstein claims his methods have the ability to cure nearly all of those patients, just using ordinary and inexpensive drugs. And he claims that he can cure these patients in a timeframe of days.
To be precise, he never uses the word "cure"; instead, he tends to use the phrase "asymptomatic, or nearly so", or something like it. Also, in the quote above, he says "feel dramatically better", and refers to a period of several days or longer. The "feel dramatically better" state is not his endpoint of treatment, as one can feel dramatically better long before one becomes anywhere near asymptomatic. From reading his books, and specifically his case reports, it is clear (and he states this in places) that he is talking about a typical period of anywhere from a day or two to months or longer to make a patient asymptomatic, or nearly so. The ten-second recoveries do indeed occur (some of them are documented in a section entitled "One Second Epiphanies" in
Tuning the Brain), but they represent a distinct minority of his cases.
Here is a quote from page 32 of
Tuning the Brain that gives a bit more insight into Dr. Goldstein's treatment schedule:
Dr. Jay Goldstein said:
The bulk of my practice is from out of town. I allot four days to treat a new patient, although only about 75 percent will feel normal by the end of the fourth day. I follow them by telephone with sample medications. Few can afford to stay into the next week. An occasional patient demands (about once a year) a refund if he or she is not well or does not remain well. I can scarcely refuse, because reporting me to the medical board will always be worse than giving a refund.
Back to your post...
Yet for some reason, nobody has paid any attention to his techniques, and so the 17 million remain uncured, their lives wasted, and the economy and insurance industry continue losing billions.
It all sounds utterly implausible.
Does it, really? Not to me.
@Hip, you live in the UK, which is generally regarded as a highly civilized country. What percentage of doctors there use state of the art knowledge to treat CFS? I'm just counting basic treatments here, not something you'd have to go to some highly specialized center to get.
So how many doctors use this available knowledge? Is it 90%? 70%? 50% Do even 10% of the doctors in the UK use state of the art knowledge to treat CFS?
I don't think so. Rounded off to the nearest percentage point, I'm afraid we would have to say that the figure is 0%. Would you disagree?
Now one could legitimately make the point that standard clinical practice typically does not use state of the art knowledge. In fact, it has been shown that it typically takes 17 years(!) for state of the art knowledge to funnel down to clinical practice. So this means that we could expect state of the art knowledge from 1998 to be filtering down to clinical practice now.
So let me be more fair here: What percentage of doctors in the UK are using knowledge about ME/CFS that was state of the art in 1998 to treat ME/CFS today?
Unfortunately, I still get the same 0% figure. Again, do you disagree?
Consider just one item that was state of the art in 1998. Dr. Lerner had just completed and published his successful trial of IV ganciclovir on ME/CFS patients.
How many doctors in the UK use IV ganciclovir, or its more commonly used successor, Valcyte, to treat ME/CFS? Please correct me if I am wrong, but I believe that the number is approximately zero - despite the fact that this is one of the most successful treatments ever found for ME/CFS.
Is it true that ME/CFS is at least treated with benign neglect in the UK? Or is the almost universal treatment for ME/CFS the Wessely School version of CBT, along with GET - both of which are known to be harmful to patients, and have been known to be so for decades?
That's the UK. The rest of Europe is even worse. In most European countries, ME/CFS is not even recognized to exist.
So here we have the example of many Western countries that are ignoring all medical knowledge ever gained about ME/CFS, much to their detriment. Aside from the professional CFS specialists, things in the US may be slightly better, but not much.
Even though there are many, many treatments that are helpful in dealing with ME/CFS - some as basic as "pacing" - the percentage of doctors in the world using these methods to treat patients with ME/CFS is approximately 0%. And these doctors are greatly outnumbered by those who either have no idea of what to do with ME/CFS (if they have even heard of it), or who try to treat it with inappropriate treatments such as exercise, or treat it as a psychiatric condition.
Considering that productive methods for treating ME/CFS are in use by almost no doctors worldwide, why is it surprising that Dr. Goldstein's methods are not being used? In a world where most doctors don't even acknowledge the legitimacy of ME/CFS, it seems to me that the lack of adoption of Dr. Goldstein's methods is quite understandable.
Dr. Goldstein also addresses this matter very directly in both the Introduction to
Betrayal by the Brain and the Preface to
Tuning the Brain, as he was questioned about the lack of adoption of his methods very frequently, typically by patients who had been helped dramatically by them. Goldstein's responses make a lot of sense to me, especially knowing what I do about the medical field. Here's what he said in 2003 about CFS research in the UK:
Dr. Jay Goldstein said:
I must say that the British CFS researchers (with very few exceptions), even more than their counterparts in the United States, don’t know they don’t know and wouldn’t care if they did. They seem to slavishly regard cognitive-behavioral therapy as the Holy Grail of CFS. Publications around the fringes of neurobiology are infrequent in number and trivial in their implications.
Any disagreement here?
I must stress that I have nothing against the UK; there's not a country in the world that deals with ME/CFS reasonably.
So if it is utterly implausible, the only alternative is to presume that Goldstein is indulging in gross exaggeration.
As I do not agree with your premise for the reasons I have stated, I cannot agree that your conclusion follows.
And consider this: the drugs that Goldstein used are very commonly prescribed drugs. If these drugs were regularly putting ME/CFS patients into remission, we would hear reports about this from all over the place.
Why do you think this is true? Dr. Sarah Myhill is one of the strongest proponents of magnesium injections, which have helped many thousands of patients of many different doctors. Yet not only did other doctors in the UK pay no attention to her success with magnesium, but it was her description of the benefits of magnesium therapy (in various forms) on her Web site that was one of the reasons cited for the attempt by many of these doctors to get her medical license revoked. It was charged that she was misleading patients, because, it was claimed, there was absolutely no evidence that magnesium was of any benefit at all in treating ME/CFS.
As Dr. Goldstein himself stresses, one has to take into account the "Not Invented Here" syndrome. It doesn't matter if a treatment works, especially for a disease that almost no one influential cares about. In the general case, what matters is whether a treatment is blessed by the appropriate institution. And among researchers, what matters is whether the treatment fits the researcher's protocol. Have you noticed that the major CFS researchers all tend to go off in their own separate directions, paying essentially no attention to what the others are doing?
I started with a 12.5 mg dose of Lamictal, and this worked fine initially, but the drug's effects disappeared after a few weeks. And even when I stopped taking the drug for a month, and then restarted, it did not help. I will at some point try to regain those effects by using a high dose, up to 50 mg. However, there were some not so nice side effects as well as the benefits, so overall on balance, the utility of this drug was only moderate.
Yes, Lamictal is a very tricky drug to administer, and it can have some truly nasty side effects. Some of these side effects may require stopping the drug immediately, while on the other hand, stopping more than a tiny dose of Lamictal immediately without titrating it down can itself have disastrous consequences. So I certainly understand your reluctance to titrate up on this drug; it's not a drug I would use. On the other hand, I don't think it's fair to judge it if you haven't used it at the doses that Dr. Goldstein recommends.
None of the treatments of his that I started have stopped working for me. (It may help that I take 16 g of inositol daily.)
16 g, wow! How long have you been taking it?
I've been taking it for about a year; I take 8 g 2x/day. I started taking it shortly before I rediscovered Goldstein's treatments.
Testosterone Gel appears on the graph on page 458 of TTB -- bottom left box under "Ketamine with down arrow".
Fascinating! This is the first time I've found a treatment listed in the chart that wasn't contained in the list starting on page 459.
dr mariano who is probably the next generation of the likes of goldstein , likes to marry up both hormones and neurotransmitters to help improve energy in many conditions.
Dr. Goldstein did some of this as well. He was an especially big fan of oxytocin.