yellowspain
Senior Member
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The rest of my blood values have not yet normalized. All my doubts focus on the methylation cycle and how to start it.Best idea to base it on a variety of blood tests. As you may know, serum B9 and B12 do show deficiency, but too high level could just mean the body can't properly metabolize and still be deficient despite high levels. Beside homocysteine also low RBC and high MCV could point to low B9 or B12 too. However, even it those markers would also show sufficiency, it is still not sure sufficient for other metabolic process requiring B9 too.
Therefore, always best to proceed cautiously, increase doses gradually over weeks, months and years. While monitoring as many lab markers possible and symptoms changes, to adjust accordingly, and as early as possible.
If homocysteine really dropped much further, which I doubt if you get enough protein in your diet, then it would be easiest to correct by decreasing B9 and B12 slightly. Along with methionine rich foods. It definitely wouldn't be serious, extremely rare, and completely reversible.
Personally, had peripheral neuropathy due to P-5-P becoming disallowed above 25 mg/d in the EU. But need above 100 mg/d for B6 sufficiency. So I used instead Pyridoxine I still had at much higher dose, and that causes neuropathy above 100 mg/d for me. It took me about 1 year to reverse the Pyridoxine induced neuropathy by reducing the dose. But beside still not sufficient in B9.
I had small fiber neuropathy due to the consumption of vitamin B6, I managed to improve by taking sam-e, but later it caused me new problems. If your folate levels do not increase, it may be due to the absence of cofactors or some absorption problem. I have low folate, despite consuming many foods that contain it.