Dose Lysine increase or lower methylation?

[Aragorn]

Hi All.
I'm on overmethylator and take Methylfolate, Methylcobalamin, Niacin and other B vitamins. Glutamine overmethylators me, so I avoid it. What about Lysine? Does it increase or lowers methylation? Any idea?

Thank you.

 

[linusbert]

you should take glycine. its a buffer for methylgroups.
bonebroth has lots of glycine.

 

[Tammy]

I wouldn't think it messes with methylation. Bottom line with any supplement is that we have no idea if we will be sensitive to it until we try it. I take it almost every day for its anti-viral properties. Always wise when starting something new to begin with low dose.

 

[xploit316]

I find all B vitamin supplements agitate and overstimulate me including glycine. Best to get it from food.

 

[Aragorn]

Thank you, all. I do take Glycine, by the way.

 

[Slushiefan]

I find all B vitamin supplements agitate and overstimulate me including glycine. Best to get it from food.

Is this what overmethylation feels like? If so I guess I have that as well. My heart rate got so high it set off my Apple Watch warnings when I took a set of B vitamins.

I was able to solve that by taking Vitamin C when I feel the rapid heart rate and sweating coming on. It goes away pretty quick once I take that. I take the same high dose B vitamins now daily, and when I feel that feeling coming on I take Vitamin C 1000mg and that feeling goes away pretty quick. I find I am doing that about every 3 days currently.

Also in general I was able to improve my ability to handle the B vitamins, which I now take daily, by adding Niacin time release.

 

[Violeta]

I accidentally found this about lysine and methylation while reading a study about COVID and ME/CFS.

I don't think it means that lysine affects methylation, but methylation somehow affects lysine. I don't understand it, but I do know that lysine helps me, I am prone to shingles, and my immediate relatives are prone to shingles.

That clip is from this link.
https://www.iomcworld.org/open-access/lc-pots-and-mecfs-lifting-the-fog.pdf

Just found this about "lysine methylation".

"Protein methylation mainly occurs on lysine and arginine residues1, 2. It is observed on histone and non-histone proteins and plays important roles in normal cellular physiology and diseases like cancer".

 

[almost]

I asked Bing AI "does Lysine increase methylation ?" and received this:

Lysine, an essential amino acid, indeed plays a significant role in methylation, a fundamental post-translational modification. Let’s explore how lysine affects methylation:

1. Lysine Methylation on Proteins:
   • Histones: These proteins package DNA into chromatin. Lysine methylation occurs on histone amino acid side chains.
   • Function:
     • Gene Expression Control: Lysine methylation influences gene expression by affecting transcription initiation.
     • Heterochromatin Formation: It contributes to forming tightly packed DNA regions (heterochromatin).
     • Chromosome Silencing: Lysine methylation can silence specific chromosome regions.
     • Transcriptional Elongation: It impacts the elongation phase of transcription.
     • Histone Exchange: Lysine methylation affects histone replacement dynamics.
     • DNA Damage Responses: Participates in DNA repair processes1.
   • Non-Histone Proteins: Lysine methylation also occurs on non-histone proteins.
     • Effects:
       • Hydrophobic and Steric Properties: Methylation provides lysine side chains with hydrophobic and steric properties, influencing protein interactions.
       • Gene Expression Regulation: Non-histone protein methylation contributes to effective gene expression regulation.
       • Other Functions: It labels proteins for cellular localization, impacts RNA processing, ribosome assembly, and cell signaling1.
2. Lysine Methyltransferases (KMTs):
   • These enzymes facilitate methylation using S-adenosyl-l-methionine (SAM/AdoMet) as a methyl donor.
   • Result: A methylated lysine residue and S-Adenosyl homocysteine (SAH)2.

In summary, lysine methylation is a versatile modification that impacts gene expression, protein behavior, and cellular processes. Its specificity and flexibility make it a crucial player in chromatin regulation and epigenetics34. So, yes, lysine is involved in increasing methylation!

I'm not sure I buy the whole argument, but that is what it offered (the conclusion doesn't convincingly come from the points above). You can make your own analysis.

 

[linusbert]

we use Lysin for our cats when they got something viral going on, and it works great for them.