• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

Does viral selection pressure on the GABAergic system mediate the etiopathogenesis of ME?


Senior Member
Berlin, Germany
i read a post from a girl in the german facebook group that had great effects and near remission by CBG Oil.
I only knew about CBD but CBG could play an important role as well!


Senior Member
I only knew about CBD but CBG could play an important role as well!

Interesting. I was aware of the effects of other Cannabinoids but I never checked these because I thought they wouldn't be available for consumers. At least that was the case last I checked, some years ago. I grew my own CBD because it's much cheaper. But the seeds were either bred for THC or for CBD, so I have no idea how the concentration of other Cannabinoids might be.

It's under investigation as an antibiotic against drug-resistant bacteria and MRSA. This sounds promising at first, but the necessary effective concentrations seem to be quite high, much more than someone would usually take. The question is if this is really necessary if it's supposed to fight chronic borrelia, for instance, which can have a very slow replication frequency.

Uncovering the Hidden Antibiotic Potential of Cannabis (2020) [10.1021/acsinfecdis.9b00419]
The spread of antimicrobial resistance continues to be a priority health concern worldwide, necessitating the exploration of alternative therapies. Cannabis sativa has long been known to contain antibacterial cannabinoids, but their potential to address antibiotic resistance has only been superficially investigated. Here, we show that cannabinoids exhibit antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), inhibit its ability to form biofilms, and eradicate preformed biofilms and stationary phase cells persistent to antibiotics. We show that the mechanism of action of cannabigerol is through targeting the cytoplasmic membrane of Gram-positive bacteria and demonstrate in vivo efficacy of cannabigerol in a murine systemic infection model caused by MRSA. We also show that cannabinoids are effective against Gram-negative organisms whose outer membrane is permeabilized, where cannabigerol acts on the inner membrane. Finally, we demonstrate that cannabinoids work in combination with polymyxin B against multidrug resistant Gram-negative pathogens, revealing the broad-spectrum therapeutic potential for cannabinoids.

I will check both for their interactions with GABA and HDACs. It will be helpful to have another option if it's selective for either one.