Does methylation increase acetylcholine in the brain?

DogLover

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What is once again illustrated by Dr. Dawn Elise Snipes in the link above is that one neurotransmitter (NT), in this case acetylcholine (ACh), is intimately involved in other neurotransmitters. No surprises. So, to try to reduce the one offending NT isn't likely going to be very effective. Perhaps a better approach would be ask the question 'Why are my NTs out of whack?' and support underlying systems.

Yes, from what I read, watch and experience, my problems are consistent with high ACh and I can indeed knock those horrible feelings down with Benadryl and KAVA, but I always wanna know why? Why is my ACh high? Is it because serotonin is low? Why would serotonin be low?

Diet? Gut? Mold? DNA?

Over the last year or so I've been making gentle gradual gains in energy and mood by supporting SE and DA production with supplements of tyrosine and tryptophan, methelation with Bs and probably more importantly, eliminating garbage from my diet.
 
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The last time I tried it was to help me sleep and I had an adverse reaction to it. It made me more anxious and more awake.
Totally same..... it made me want to jump out of my skin and turn it into moccasins and a nice little rain hat ....

Have you tried Unisom ? This is the second time today that I've rec'd it, so I want to state clearly that I have absolutely no connection to any company, corporation, person, entity, or cash register associated with Unisom .... it just really works for me, sleepwise .....

It works incredibly well for me for sleep issues .... but just a quick warning: I'm pretty sure it's an acetylcholinesterase inhibitor. I wouldn't swear to it, but maybe do a fast google if that part worries you ....
 

DogLover

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Totally same..... it made me want to jump out of my skin and turn it into moccasins and a nice little rain hat .... (speaking of Benadryl)
Yes, it seems that it can go either way with Benadryl. Some people it drives them batty, and others, like me, it calms them down. It makes me think that this all boils down to some immune response. Probably driven by the gut, but who knows?
 
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I take 600 mg holy basil, 25 mg 5 HTP
Holy Basil and %HTP also turned on me, after beng OK for quite a while.
.5 mg or 500 mcgs melatonin
I do tolerate melatonin well, and most nights it does the trick, along with a solid dose of mag gly and a teeny tiny amount of glycine in the form of a littl gelatin powder ...
An absolute blessing !!!


I can only go so long on poor, spotty, or absent sleep, which is when the 1/4 or 1/3 Unisom is like a total life-jacket, and seems to edge my system back into more normal rhythms, at least until the next time ....
 

dannybex

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I think I have high acetylcholine levels. Anything that increases acetylcholine makes me depressed, fatigued and anxious. Things like choline, phosphatidyl-choline and huperazine, all make me feel horrible. Because they all increase acetylcholine.

Improving methylation makes me feel better and more energized. So in my experience, it doesn't raise acetylcholine levels.
Yeah, I agree. Methylation may gradually help to improve choline synthesis, but as Dog Lover has pointed out (and I have a few posts on PR over the years) many foods, and many herbs inhibit acetylcholinesterase, the enzyme that breaks down acetylcholine -- and B12 and carnitine are two things that help increase the activity of that enzyme. So they should LOWER acetylcholine.