I remember to have had ticks when I was four years old. It also had some impact that never went away, I of course wasn´t aware of it, only things tended to be a bit difficult, whereas before I now remember to have been very agile.
After EBV I got uncomfortable ill. I think ticks have been the first impact.
The borrelia contain tremendous amounts of manganese (Aguire et al 2013, cf already Posey and Gheradini 2000). I think the bacteria itself (only very very few ones are found) are unimportant. However, low Mn helps me since four years, still improving. After a jaw infection there seems to be something wrong with my jawbone, having changed shape, maybe due to low Mn.
Mn is important for tissue and bone built up, generel speaking this might be dysregulated anyway. My improvement seems to be in first place due to the influence on iNOS, Filipov et al, 2004 or 2005, Filipov even has written two papers, also Chen et al 2006, I think. One of the Filipov articles is currently open access, last year the other one was.
Edit: The iNOS can act on nerves. Nerves then, I think, are a the best candidate for explaining Delayed PEM and the Possibility of Pacing (same quantity of exertion).