No, the CBS studies seem to be solid and consistent. Yasko's claims about the CBS SNPs contradicts the science, and many other methylation sources simply parrot her.
If you can provide a link to a published paper showing that those CBS SNPs can cause problems, many of us would be very interested to see it.
Science isn't about opinion. It's about evidence. There is evidence that CBS C699T "+/+" causes a very mild and slightly beneficial up-regulation of the CBS gene. There is no evidence that any of the CBS SNPs listed by Yasko cause any problems. This can be seen by searching and reading the research.
Yes - but someone calling herself a doctor should be interested in accuracy. Reporting a dozen or more SNPs to cause problems when there is literally no basis for it is not simply an innocent error. And since her forum expressly forbids any "negative" opinions or discussions, it would seem that she is not interested in seeing her mistakes corrected.
Like what? Science?
Basically the only CBS SNPs which have a major impact and cause any sort of problems are the ones which cause large down-regulations of the gene. The only actual excessive up-regulation in the real world is in the case of Down Syndrome, where there are three copies of the CBS gene (and the rest of the chromosome). Yasko somehow equates a very mild and very common minor up-regulation with the extreme up-regulation seen in Down Syndrome or when removing half of the entire gene in an experiment involving a lab yeast. It's nonsensical.
That would be a complete down-regulation of the gene. Yasko suggests that it's a mild and common up-regulation which is somehow catastrophic.
There have been formal studies for some of the SNPs, which prove Yasko wrong. The others lack research, but that doesn't leave room for playing guessing games as a result. It is known that most SNP variants in the human genome do not have an impact, so if making any guess at all, it should be that a SNP is harmless until proven otherwise. And even if guessing that a SNP does something, you'd have to flip a coin to guess if it's an up-regulation or a down-regulation.
I'm afraid I don't see the relevance. Challenging disproven and unfounded claims has nothing to do with relationships, and I will continue to challenge those claims.
Thanks, I do avoid the B6 in favor of the P5P.
I think a lot of us do.
The reason is that I have issues with converting Sulfites and that causes toxicity issues. As a result I place limits on my Sulfur intake to keep those clear.
@Skippa
The resveratrol and calcium pyruvate still working?@Jigsaw, @eljefe19, @xena - I've been struggling with severe insomnia for several months following a slow-taper off of 1 mg. lorazepam (on it for 10 years! in the middle of the night for sleep, ironically enough).
So I've been taking lots of l-theanine and several others things, mostly to no avail. And then read just recently that as @xena said, l-theanine could be converted to glutamate. And then read in a couple of threads and Benzo buddies that perhaps it would be better to focus on getting rid of excess glutamate, instead of trying to increase GABA.
I'd also been taking lots of l-glycine which at one time did help with sleep, but then I read again just recently that it could also be converted to glutamate, so have stopped it as well.
This all led me to calcium pyruvate and resveratrol which are glutamate scavengers - and it's been amazing. I've finally started to sleep again. I got 8 hours last night - I can't remember the last time I did that. I'm also taking niacin and lots of magnesium, and 5-htp and relora. But have pretty much cut out l-theanine and GABA supps.
I also read that glutamate is the gun, and calcium is the bullet that gets it into the cells (or something like that! it doesn't sound quite right here
So @eljefe19, you might want to try the pyruvate and resveratrol. I am so surprised at how well they're working - I'd almost given up the idea of getting a good night's sleep.
And I was on a very low dose, maybe 0.25 mg. or 0.5 max.@flitza - dang! sorry to hear that about the alpha stim ... someone else told me that it had helped them. I presume you recovered from the harm you felt it did to you, I hope?
I've tried ldn at least twice and possibly 3 times, can't remember. But each time it made me quite spacey and tired such that it was hard to function - e.g., the first time I tried it we had heavy rains and I remember watching my living room ceiling leak for 3 days before it occurred to me that I should do something about besides putting out buckets ... that made me realize I'd better stop the ldn
I've never had a sleep study and don't know how it could be helpful. There is no question my sleep is in the toilet and the severe insomnia has hit I am certain because of the lorazepam taper. I've been off it 3 months now and from what I read, it's not unusual to have problems for a year or more after stopping, which is hard to think about. I'm presuming that if a sleep study shows abnormalities, the remedy will be to hand out something like Ambien which I don't want to take. I don't have symptoms of sleep apnea. If doctors were truly helpful with sleep besides handing out ambien and anti-depressants, then I guess I would be willing to have a sleep study done. But I've never heard of them having any real solutions.
I did have sleep problems for several years before starting the lorazepam 10 years ago (which is why I started it). I did have high cortisol at night at one time and Seriphos was great for that, but that does not seem to be the issue here.
I may give coffea cruda a try, I took it years ago and I think it was a little helpful, though I don't know if it could touch what I'm going through now.
I'm also thinking of giving acupuncture a go, but it's expensive and not covered by Medicare and I believe you have to go a lot to get relief. So I probably can't afford it. If it only took a few visits, I could do that.
One more thing I thought about today is reflexology - it might be helpful - and something maybe I could do myself.
Or I may just hired someone to knock me over the head each night!
