gbells
Improved ME from 2 to 6
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- 1,494
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- Alexandria, VA USA
Circadian rhythm doesn't impact cortisol level only,
between 11AM and 2 PM Orexin decreases in the brain, Melatonin raises in the brain, Blood Pressure decreases, Histamine and Dopamine raise in the brain.
My brain fog is related to a sleepy state, and it clearly picks very quickly after 11 AM.
Low Dopamine is associated with restless legs, headache, hyperalgesia/allodynia, which I have all so I know it's a problem for me.
If I take Methylphenidate in the morning, my pain drops immediately and I can be awake for 3 hours.
But after 11 AM, I need twice the morning dose to stay awake and fight the sleepiness/brain fog/headache/pain state.
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Frontiers | Plasma Orexin-A Levels Do Not Undergo Circadian Rhythm in Young Healthy Male Subjects | Endocrinology (frontiersin.org)
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this graph is from a schizophrenia study, but I took it to show the lowest Dopamine at 12 AM
Schizophrenia: the role of sleep and circadian rhythms in regulating dopamine and psychosis in: Reviews in the Neurosciences Volume 27 Issue 7 (2016) (degruyter.com)
Melatonin doesn't get going until 9PM. The psychosis correlation is very interesting. At one point pre ME I was getting panic attacks at night for months during a period of depression caused by a life crisis. Maybe it was related to the low dopamine from the circadian rhythm.
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