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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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most people don't just have one generic immune response to all "triggers"
other cells than mast cells, such as glial cells and macrophages.
i just wanted to point out that idiopathic is for idiots, in my opinion. there is always a cause
i think when you look at all the environmental changes of the last forty years that seems more likely to be involved than genetic changes
Thanks for expounding on this point with more detail. Sincerely, I knew there were other cells involved in immune response but didn't have the energy to put that level of detail and that was helpfulGood point. The "sentinel cells" of the immune system are those immune cells that normally live outside the blood, patrolling for external or internal threats to homeostasis. So far, we know about three different types of sentinel cells:
1) Tissue-resident macrophages. These cells live inside tissues, patrolling for threats. For purely historical reasons, tissue-resident macrophages have different names depending upon the tissue in which they live. In the dermis, they are called Langerhans cells. In the liver, they are called Kuppfer cells. And in the brain, they are called microglia.
2) Tissue-resident memory T cells. These cells also live inside tissues, patrolling for threats. These are currently a hot research topic.
3) Mast cells. These cells live in tissue barriers, not inside the tissue itself. They patrol for threats on the boundary of tissues.
I didn't say anything about mold spores being to blame in all casesAnd while what led to one's mast cells becoming super-sensitized may be determined at some point (though perhaps there is more than one cause in at least some cases), there are too many diverse symptoms to say that something like mold spores are to blame in all cases
Could be related to mcas but just as easily could be related to brainstem glutamate