It looks like from
this paper that astressin-B is a non-selective CRF1 and CRF2 antagonist, and astressin2-B is a selective CRF2 antagonist. Since we would want to target CRF2, astressin2-B would be best, but the astressin-B found in hair loss products might suffice.
Astressin-B is found in the
Spectral.F7 hair loss product, whose ingredients are:
But as discussed above, since the molecular weight of astressin-B is 4042 daltons, and both the human skin and blood-brain barrier have a 500 dalton limit to the molecules that can cross them, getting astressin-B into the brain is a problem.
It is possible that intranasal administration of astressin-B might work, because the intranasal route apparently bypasses the blood-brain barrier; but there is still around a 2,000 dalton limit for molecules crossing the nasal mucous membranes, so it would be a long shot if any astressin-B got through.
There are a couple of other CRF2 receptor antagonists listed
here: antisauvagine-30 and K 41498, but they both have molecular weights in the 3,600 dalton region.