Cortene Peptide for MECFS? "Curative"?!

Neunistiva

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These guys have this drug and are just desperate for something it might work on. The odds it has any effect are, at this stage, probably tiny.

But that's better than nothing, I guess!
I would be very sceptical and share your sentiment if they were trying to sell us something right away. But isn't this a private company taking a huge risk and conducting a proper scientific trial?

What do we have to lose? They are the ones taking all the risk.
 

Diwi9

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Pure speculation, but Chheda and Kaufman left OMI to focus on clinical practice. Kogelnik was said to be taking the research route. My guess is that this company will be working the trial through his office.
 

shannah

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Pure speculation, but Chheda and Kaufman left OMI to focus on clinical practice. Kogelnik was said to be taking the research route. My guess is that this company will be working the trial through his office.
I thought I read the trials would take place in Utah.
I would think that would be Lucinda Bateman.
 

Diwi9

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I thought I read the trials would take place in Utah.
I would think that would be Lucinda Bateman.
Cort's post did reference Lucinda Bateman...but I thought there was reference to a California-based specialist. We'll find out soon enough...hopefully!
 

Navid

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Could this have something to do with stmts Dr. Chia made to a patient in recent weeks about some important treatment breaththrough occurring soon. There was a post from a Chia patient last week or the week earlier.

I wonder if Dr. Kaufman and Dr. Chedda (sp?) know anything about this....and yes, what about Dr. Davis and OMF?

I hate when stuff like this is all cloaked in mystery. Why will it take Cort 3 blogs to release the full story?

We've already been waiting 25+ years isn't that enough time to build suspense.

Thanks for the initial info though, very much appreciated that there may be something to look forward to in terms of treatment. Especially a treatment that might actually fix us and not take a million years and treatments to do so.

@Ben H (any info from OMF avail?)

: )
 
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neweimear

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Does anyone know how long it takes for a drug to go through trials before hitting the market? I assume if this drug works for a cohort, the process may be hurried along since we have no approved treatments for our disease?
 
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Sorry everybody for seeming like a big old grump. I am pleased someone cares about us enough to run a trial. And I am pleased they're doing a trial before selling the drug. I don't think the probability of success is exactly zero.
 
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It looks like from this paper that astressin-B is a non-selective CRF1 and CRF2 antagonist, and astressin2-B is a selective CRF2 antagonist. Since we would want to target CRF2, astressin2-B would be best, but the astressin-B found in hair loss products might suffice.

Astressin-B is found in the Spectral.F7 hair loss product, whose ingredients are:


But as discussed above, since the molecular weight of astressin-B is 4042 daltons, and both the human skin and blood-brain barrier have a 500 dalton limit to the molecules that can cross them, getting astressin-B into the brain is a problem.

It is possible that intranasal administration of astressin-B might work, because the intranasal route apparently bypasses the blood-brain barrier; but there is still around a 2,000 dalton limit for molecules crossing the nasal mucous membranes, so it would be a long shot if any astressin-B got through.


There are a couple of other CRF2 receptor antagonists listed here: antisauvagine-30 and K 41498, but they both have molecular weights in the 3,600 dalton region.
I don't know if it will cure your CFS, but it could grow a lot of nose hair.
 
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Does anyone know how long it takes for a drug to go through trials before hitting the market? I assume if this drug works for a cohort, the process may be hurried along since we have no approved treatments for our disease?
Cort suggested in the comments under the blog post that it could take several years to get through phase ll and phase lll trials.

However, if the early studies are successful it may be a candidate for designation as a "breakthrough therapy", as we recently saw with MDMA for PTSD, which would expedite the review and possible approval of the drug. This status is granted when "preliminary clinical evidence indicates that the drug may demonstrate substantial improvement" (over other available therapies) per the FDA's website.
 

Hopeful1976

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Could this have something to do with stmts Dr. Chia made to a patient in recent weeks about some important treatment breaththrough occurring soon. There was a post from a Chia patient last week or the week earlier.

I wonder if Dr. Kaufman and Dr. Chedda (sp?) know anything about this....and yes, what about Dr. Davis and OMF?

I hate when stuff like this is all cloaked in mystery. Why will it take Cort 3 blogs to release the full story?

We've already been waiting 25+ years isn't that enough time to build suspense.

Thanks for the initial info though, very much appreciated that there may be something to look forward to in terms of treatment. Especially a treatment that might actually fix us and not take a million years and treatments to do so.

@Ben H (any info from OMF avail?)

: )
I also would like to know why the info about this is being withheld in favour of 3 separate blogs... why make us wait? It seems cruel actually. I can't think of a good reason why?...
 

junkcrap50

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I also would like to know why the info about this is being withheld in favour of 3 separate blogs... why make us wait? It seems cruel actually. I can't think of a good reason why?...
Cort's probably writing a lot on the topic, so he broke it up into 3 parts. He might not have finished parts 2 and 3 yet, but wanted to publish the first part now.
 

Ema

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I also would like to know why the info about this is being withheld in favour of 3 separate blogs... why make us wait? It seems cruel actually. I can't think of a good reason why?...
Many people with MECFS have trouble processing such a huge amount of information all at once. He does it to help increase comprehension, I'm sure, when the topic at hand is fairly long and complex. It's not like we can all rush out to try it tomorrow anyway, so I don't see the harm. I think it's helpful given so many of us struggle with brain fog and reading in general.
 

neweimear

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Many people with MECFS have trouble processing such a huge amount of information all at once. He does it to help increase comprehension, I'm sure, when the topic at hand is fairly long and complex. It's not like we can all rush out to try it tomorrow anyway, so I don't see the harm. I think it's helpful given so many of us struggle with brain fog and reading in general.
Absolutely, where would be without Cort, he keeps us informed and also keeps hope alive. I think he does an amazing job.