A word of caution
: these microglial activation inhibitors may have caused me to crash.
Last week I took a set of these microglial activation inhibitors as an experiment. On the first day taking them, I found I had a rapid boost in energy and enthusiasm, and this led me to spend 5 intense hours doing lots of house cleaning and dusting, washing floors, moving furniture around, etc. I don't usually get much PEM from physical activity, so the next day after this cleaning spree I felt a little tired, but nothing more than that. I took the microglial activation inhibitors for a second time on that second day. Later on that second day, I went out socially for the evening (I usually find socializing more exhausting than physical activity).
On the third day, I found myself much more exhausted than I would normally be after socializing. I was concerned that the microglial activation inhibitors might have been the cause of this increased PEM, so I stopped taking them entirely. However, as the week progressed, I found that the increased fatigue remained, so I realized I had precipitated a mini crash.
It is possible that these microglial activation inhibitors I took may have caused this mini crash, which I am still not really recovered from 1 week later.
The set of microglial activation inhibitors that I took for those two days in a row were:
Microglial activation inhibitors
Hyaluronic acid 400 mg transdermal
Lithium orotate 60 mg
Vitamin D 10,000 IU
Turmeric 1000 mg
Vitamin E 400 IU
Chinese skullcap (4:1 extract) 400 mg
Genistein 56 mg
Lycopene 10 mg
Sulforaphane 400 mcg
N-acetyl-glucosamine 750 mg
Sesame seed oil 10 ml
Acetate (vinegar 2 tablespoons)
Siberian ginseng 5 grams
Terminalia chebula 1000 mg
Vinpocetine 10 mg
Reishi 600 mg
Curcumin 900 mg
Horny goat weed (Epimedium) 900 mg
Luteolin 100 mg
Fisetin 100 mg
I took the above just because I happened to have all of these supplements in stock from previous supplement experiments.
Given my experience with these microglial activation inhibitors, I am just sounding a note of caution for anyone considering taking them. It's possible, as @Marco
suggested earlier in this thread, that by strongly inhibiting microglial activation, you are lowering the ill effects of brain inflammation (which is good), but you may also be reducing antiviral defenses in the brain (which is bad).
Though I cannot rule out the possibility that my intense 5 hour house cleaning spree may have played a role in my mini crash.
When I recover, I may try these microglial activation inhibitors again, but this time using a smaller set of them (perhaps only taking say 6 or 7 of the above supplements, rather than the full set of 20 I took).