Yes, this was a great read! I did a review of it, https://9gurus.com/how-microglia-brain-cells-contribute-to-chronic-illness/Donna Jackson Nakazawa: "The Angel and the Assassin" is a good read on microglial activation. She suggests fasting, neurofeedback, transcranial magnetic stimulation, gamma flickering light and fasting as remedies.
To the end, the study revealed that microglia is critically involved in stress-induced neuroinflammation, which may underlie the molecular mechanism of CUMS-induced anxiety behavior.
Our results suggest that minocycline modulates LPS-induced microglia and astrocytes activation as well as improves learning and working memory comparable to memantine. Thus, minocycline may have preventive-therapeutic effect in diseases involving neuroinflammation such as AD.
But not an area I really understand much about the underlying systems and I have trouble following it.
I find paracetamol extremely useful in reducing brainfog and also as a PEM preventer.
Both candesartan and telmisartan were able to shift BV2 murine microglial cells towards their neuroprotective phenotype (M2) suggesting, therefore, an important role for these two drugs on modulating brain response to inflammatory stimuli (Torika et al., 2018, Torika et al., 2016a).
Moreover, Bhat et al. also reported a reduction in STAT3 activation contributing to decreased gliosis (Bhat et al., 2016).
Indeed shifting microglia to its neuroprotective state is of utmost importance in neuroinflammatory diseases, including AD