Dear support
I went down with double pneumonia about 3-4 months ago. After 10 days I was put in cygnet taunton. I was so I'll I could barely cope...I couldn't really get much help...
The doctor did question me about m.e. he said do you believe you have m.e.
Anyway I don't really want to moan buy I can't see a way out of clozapine. Anyway last week I went down with pneumonia again..it was hell and still is.
Hello Brian,
I am very dismayed to learn that you have pneumonia yet again and at this time of the year too. I don't think there can be any doubt that this is the result of taking clozapine. I recall way back just before you were about to be put on it, you had neutropenia and the guidelines for administering clozapine says it must not be given in such a case. Prof Hooper wrote to Dr D and emphatically told him you must not be given it as an ME patient. Dr D ignored the warning of course. Then I recall the female locum raised the issue when she found you had a low white cell count and alerted the ward to the fact that, in your circumstances, clozapine was countra-indicated. There was some record in your notes saying no one on the ward could find any guideline available to them that they could refer to and it was again left unresolved.
I think it might be an idea to ask them to provide you with the written results of your latest blood test to check your blood counts again.
I have found this which confirms that clozapine is associated with pneumonia. I think you have every right to demand to be switched to another drug as it is unconscionable that you continue on this drug.
Int Clin Psychopharmacol. 2017 May;32(3):155-160. doi: 10.1097/YIC.0000000000000162.
Clozapine usage increases the incidence of pneumonia compared with risperidone and the general population: a retrospective comparison of clozapine, risperidone, and the general population in a single hospital over 25 months.
Stoecker ZR1,
George WT,
O'Brien JB,
Jancik J,
Colon E,
Rasimas JJ.
Author information
Abstract
The aim of this study was to determine whether the incidence of pneumonia in patients taking clozapine was more frequent compared with those taking risperidone or no atypical antipsychotics at all before admission to a tertiary care medical center. This was a retrospective, case-matched study of 465 general medicine patients over a 25 month period from 1 July 2010 to 31 July 2012. Detailed electronic medical records were analyzed to explore the association between the use of two atypical antipsychotics and incidence of pneumonia. Of the 155 patients in the clozapine group, 54 (34.8%) had documented pneumonia compared with 22 (14.2%) in the risperidone group and 18 (11.6%) in the general population group. Clozapine, when compared with the untreated general population, was associated with an increased risk of pneumonia (odds ratio=4.07; 95% confidence interval=2.25-7.36). There was, however, no significant increase in the risk of pneumonia associated with the use of risperidone (odds ratio=1.26; 95% confidence interval=0.65-2.45). Clozapine use is associated with increased risk of pneumonia that may be related to immunologic factors or side effects of sedation and drooling that make aspiration more likely, although causative mechanisms require further investigation. These findings suggest that providers should use added caution in choosing candidates for clozapine therapy.
PMID: 28059928 DOI:
10.1097/YIC.0000000000000162
[Indexed for MEDLINE]
I am going to inform the two doctors who are concerned about you.
I wish I could get to see you Brian, but am rather unwell as ever and we no longer have Annie to drive to you, of course.
Please keep in close contact.
Where are you in Torquay right now?