Bhupesh Prusty: "we are on a perfect path for identifying potential transferable factors in ME/CFS blood that can cause mito dysfunction..." GoFundMe

[raghav]

Follow live tweets from the conference here

https://twitter.com/hashtag/CMRC2020?src=hashtag_click

 

[raghav]

https://twitter.com/i/web/status/1237316426341507074

 

[junkcrap50]

Follow live tweets from the conference here

https://twitter.com/hashtag/CMRC2020?src=hashtag_click

Do we know if anyone will be live tweeting it? With overviews of the presentations? I don't know if the conference is open to the public or CFS advocates/patients.

 

[raghav]

Yesterday some people have been posting screenshots and comments on twitter

https://twitter.com/i/web/status/1237423615869681665

You may watch these two above.

 

[raghav]

They have modified the pdf and Prusty is talking at 2:45 pm GMT after Dr. VanElzakker (2:15 pm).
https://www.actionforme.org.uk/uploads/images/2020/03/CMRC_2020_programme_Final.pdf
The title - Infectious etiology behind Mitochondrial architecture and Cell danger response in ME/CFS - Dr Bhupesh Prusty, University of Wuerzburg

 

[Canned]

I wonder what the mitos look like under Prustys microscope when you add some ss-31.

 

[raghav]

https://twitter.com/i/web/status/1237755396309295105

https://twitter.com/i/web/status/1237755978721964032

https://twitter.com/i/web/status/1237756355345371136

https://twitter.com/i/web/status/1237756843201527809

Upto 40 % of ME/CFS patients showed positive signal for HHV-6A sncRNA-U14 in comparison to 0% in healthy controls.
Only a tiny fraction of blood cells were positive for HHV-6

 

[raghav]

https://twitter.com/i/web/status/1237755978721964032

In the slide the blue blob (mystery molecule is DAPI )
Edited -
DAPI (pronounced 'DAPPY'), or 4′,6-diamidino-2-phenylindole, is a fluorescent stain that binds strongly to adenine–thymine rich regions in DNA. It is used extensively in fluorescence microscopy.

So the mystery molecule must be sncRNA U14

 

[raghav]

 

[raghav]

https://twitter.com/i/web/status/1237764295292850176

 

[raghav]

 

[raghav]

https://twitter.com/i/web/status/1237766621625831427

 

[paul80]

So why do you think it's only 40% of M.E patients and not higher?

 

[raghav]

https://twitter.com/i/web/status/1237780800143269892

 

[sb4]

So why do you think it's only 40% of M.E patients and not higher?

Perhaps this is the mechanism for only a subset. Maybe some of the other 60% will have RNA or something from some other virus.

 

[paul80]

let's hope we're in the 40% group then.

 

[raghav]

I think the mystery molecules are sncRNA U14, Human U6 snRNA and the last one on the screen says Scrambled RNA(Dont know what he means by that- Is it varying from person to person)

 

[Canned]

Is that the cause? A local infection in the brain and „immune cells within perivascular spaces“ that send out a signal, as a response to the infection, that causes a cellshutdown

 

[raghav]

Perivascular spaces, also known as Virchow-Robin spaces, are pial-lined interstitial fluid-filled spaces in the brain that surround perforating vessels. They do not have a direct connection with the subarachnoid space and in fact, the fluid within them has a slightly different composition as compared to CSF.

 

[raghav]

https://twitter.com/i/web/status/1237774801332297728