i’ve micro and macro dosed psilocybin with cfs. i was undiagnosed at the time and didn’t know i had cfs, but knowing of the benefits i decided take the leap. i had previously used psychedelics 6 or 7 times before developing cfs. in college i was introduced to terence mckenna, alan watts, robert anton wilson, and timothy leary, among others. they sparked my interest in the drugs. if you aren’t familiar with them i highly recommend their books or lectures. they are wacky and yet incredibly intelligent with wide open minds. very entertaining figures. the use of psychedelics changed my life drastically for the better. i used them therapeutically for self growth during that time of my life.
anyway, my experiences using psychedelics while having cfs have not been great. the micro doses exacerbated my brain fog, although improved my mood (as they always have when done in the right setting). my most recent macro dose on psilocybin was a bit traumatizing however. i felt like i was dying and it was difficult to handle mentally. i was undiagnosed but having a good day so i decided to drop about 2.5 grams since i had missed the experience of tripping. it very quickly triggered pem. the feeling of pem + being undiagnosed was a recipe for a bad experience. being diagnosed i think i could handle a macro dose emotionally and the experience wouldn’t be traumatizing, potentially therapeutic. i’m not ready to try that though. if i had mild severity i would consider it.
using psychedelics is one of the things i miss a lot about feeling well, oddly enough. it makes me feel like a drug addict to say that, but i very little used them and they also terrify me. when i did have the courage to use them however, i had profound “spiritual“ experiences, if you will.
There are a few threads already about ketamine you can search for. 