@CSMLSM do your treatments help with anxiety? My wife has bad anxiety and panic attacks every day, especially in the evenings.
Hi
@Husband of, yes what I use for my treatment does work for anxiety, it directly targets the HPA axis which is responsible for the regulation of stress and thus anxiety.
In order for the treatment to work effectively you must have good levels of omega 3 and vitamin B12. These two things are very commonly low/deficient in many people who have ME/CFS and fibromyalgia.
Basically cannabidiol(CBD) and also caryophyllene act as enzyme inhibitors of an enzyme called fatty acid amide hydrolase(FAAH).
This enzyme is responsible for degrading and reducing the amount of a few things that will help your loved one.
One thing is oleamide which is related to sleep and in sleep deprived people it naturally increases to induce sleep, so more of this will help with better quality sleep.
Another is anandamide which is related to your question. Anandamide is responsible for many things and one of those things is regulating the HPA axis which is responsible for stress and anxiety. Anandamide also works like an antidepressant due to this regulation of stress and anxiety via the HPA axis.
CBD as well as being a FAAH inhibitor works to prevent tolerance to CB1 and CB2 receptors so any endogenous cannabinoids you have will go further. Anandamide is an endogenous cannabinoid and oleamide is classed in with this also.
Caryophyllene has a different action as it is a selective CB2 agonist. This just means it will only bind to the CB2 receptor which is mostly found in the immune cells of the immune system. Its activation helps direct the immune system away from an inflammatory adaptive immune state to a more naturally better state of innate immune system.
It will also cause B cells that are infected with epstein barr virus(EBV) to self destruct via a process called apoptosis. This means that enzymes are released within that cell that completely breakdown everything inside the cell even the EBV. B cells are part of the adaptive immune system.
Palmitoylethanolamide(PEA) is also increased when FAAH is inhibited and has many positive attributes too.
Here is a recovery thread that mentions using PEA just incase you would like to try that on its own.
https://forums.phoenixrising.me/threads/daughters-recovery-details.90429/
It is easily accessed and does not carry the stigma of coming from a cannabis plant like CBD.
I obviously benefit from it also as I use FAAH inhibitors but maybe it could work for your loved one on its own.
I have included the detail so you may easily find information online when you look this stuff up.
Good luck and did you try the epsom salt baths before or get a supplement that worked? Magnesium is involved in regulating stress also so would be best to target that too.
