Antivirals Effective Against Coronavirus?

[Rufous McKinney]

If you can, just grab a bicycle, it's healthier

can't exercise, due to ME ....exertion is intolerated.

 

[Wayne]

This well-done 5-minute video made an awful lot of sense to me. In fact, it sorta feels like I found a gem.

How to kill Corona Virus at home, COVID 19 by Dr Dan Lee Dimke, PhD. Hot air therapy

 

[Hipsman]

How to kill Corona Virus at home, COVID 19 by Dr Dan Lee Dimke, PhD. Hot air therapy

This is interesting, here is the full video. I assume this would only work early on, say within first day of exposure since the virus travels to lungs where it replicated.
Edit: in the description it says:

NOTE: Once the virus has migrated to the lungs, which may occur in up to 20% of patients within one to two weeks, the virus is too far from the external heat source to be substantially impacted by inhaling hot air. Benefits are likely to be highest when used for prevention and early treatment.

 

[junkcrap50]

This well-done 5-minute video made an awful lot of sense to me. In fact, it sorta feels like I found a gem.

How to kill Corona Virus at home, COVID 19 by Dr Dan Lee Dimke, PhD. Hot air therapy

Funny enough, back in February I came across random posts online (not on PR) of people who do this exact technique for prevention in flu season. I thought they were joking, but after the 3rd unique post, it's plausible.

Best used for prevention, immediately after exposure, & very early infection. I don't see any harm in not doing it. Probably won't work if you get an initial huge viral load, as many are speculating, now assuming, load seems to be correlated with severity.

 

[Wayne]

This is interesting, here is the full video

@Hipsman -- Unfortunately, I didn't watch this earlier when you first posted the link. I just went to watch it and got the following message: -- "This video has been removed for violating YouTube's Community Guidelines". Sheesh!

 

[Hipsman]

"This video has been removed for violating YouTube's Community Guidelines". Sheesh!

YouTube is on a rampage now, deleting everything automatically without review b/c review staff is off for quarantine.
There is another video that is yet to be removed here, videos like this get to be removed from time to time, you may search YouTube for "Dr Dan Lee Dimke, PhD. Hot air therapy" and see whats available.
I've archived the newly linked video to google drive

 

[pattismith]

I got anosmia for 10 days, so wonder if I got a Covid-19 light disease… and so does my husband.
Note that we will know only when the outbreak will be over!

I had a look at the supplements we are taking and what may have been protective (this is pure speculation as none of us was tested, nor the ill people i was in contact with!)
(Remember my husband has low lymphocytes count under 1000/mm3 and I have low CD8 with CFS/ME/FIBRO and SFN)

We both take Vit C 1 g x3
We both take Lysine 1g x3
We both take Lipoic acid 300 mg x3 for him and 600 mg x3 for me
We both take Lactoferrin 400 mg x2
We both take Selenium methionine (150 microg of se), vit D, Propolis
and Curcumin and vit K2 and Fucosyllactose
I also take Salicylic acid and Desmodium and also Inosine 500 mg x3 (and ginger root infusion)

Here an in vitro 2016 study I found

D, L-lysine acetylsalicylate + glycine Impairs Coronavirus Replication

Abstract
Coronaviruses (CoV) belong to the large family Coronaviridae within the order of Nidovirales. Among them, several human pathogenic strains (HCoV) are known to mainly cause respiratory diseases. While most strains contribute to common cold-like illnesses others lead to severe infections. Most prominent representatives are SARSCoV and MERS-CoV, which can lead to fatal infections with around 10% and 39% mortality, respectively.

This resulted in 8098 casualties in the 2002/2003 SARS-CoV outbreak and in 1806 documented human infections (September 2016) during the recent on-going MERS-CoV outbreak in Saudi Arabia. Currently patients receive treatment focusing on the symptoms connected to the disease rather than addressing the virus as the cause.

Therefore, additional treatment options are urgently needed which would ideally be widely available and show a broad affectivity against different human CoVs.

Here we show that D, L-lysine acetylsalicylate + glycine sold as “Asprin i.v. 500mg®” (LASAG), which is an approved drug inter alia in the treatment of acute pain, migraine and fever, impairs propagation of different CoV including the highly-pathogenic MERS-CoV in vitro.

We demonstrate that the LASAG-dependent impact on virus-induced NF-κB activity coincides with (i) reduced viral titres, (ii) decreased viral protein accumulation and viral RNA synthesis and (iii) impaired formation of viral replication transcription complexes.
….
Several other drugs were also shown to impair MERS-CoV replication in cell culture including cyclosporine, chloroquine, chlorpromazine, loperamide and lopinavir [21-23]. Whether these drugs will be useful in future treatment of HCoV infections remains to be investigated.
...

ASA (acetyl salicylic acid) as well as other salicylates are able to block the activation of NF-κB [32,33] via inhibition of IKK2 in a low millimolar range [34]. The transcription factor NF-κB is essential for cell responses to infection with various pathogens. It controls expression of a variety of anti-viral cytokines and it regulates apoptotic gene expression.

Therefore, it is considered to be a main mediator of the anti-viral cell response to viral infection [35]. Besides the wide usage of ASA in pain therapy, it was shown that ASA-mediated inhibition of the NF-κB
dependent induction of TRAIL and Fas/FasL, reduces influenza virus propagation [36-38].

ASA also displays anti-viral activity against cytomegalovirus [39] and human rhinoviruses [40]. As SARS-CoV was shown to activate NF-κB in the lung tissue of infected mice and NF-κB-inhibition (using CAPE, resveratrol, BAY11-7082 or parthenolide) improved survival rates of SARS-CoVinfected mice [41], we speculated that NF-κB activity might be important for efficient CoV propagation.

We therefore investigated whether NF-κB inhibition via the clinically tested and approved LASAG could negatively affect CoV replication.


This hypothesis was analysed by LASAG treatment of cells infected with the low pathogenic human strain HCoV-229E as well as the high pathogenic MERS-CoV.

Our results could demonstrate that LASAG interferes with virusinduced NF-κB activation, the formation of viral replication transcription complexes, viral RNA synthesis and viral protein accumulation resulting in an overall impaired CoV propagation.

@Hip @junkcrap50 @Wally @Learner1

 

[Wayne]

There is another video that is yet to be removed here,

Hey @Hipsman -- Thanks for reposting a link to that video. I've only watched half of it, but I paused watching when I ran across something that really gave me a deeper appreciation for the perspective I've mostly adhered to, and it has to do with prevention. -- This is what was said at the 8:00 to 8:17 mark, only 17 seconds. I wish I'd have run across this much earlier:

"The initial upper respiratory infection ALWAYS starts in the nose and sinuses. And usually lingers there for two days to as long as two weeks before progressing. And it is here--within the sinuses--that the invading virus is most easily defeated...by applying external heat."​

​

I happen to think that the Hydrogen Peroxide Inhalation Method, and the Sinus Cleanse using iodine drops I mentioned earlier would likely be equally effective. But if not, it would seem they would at least augment the external heat therapy. For convenience, I'll go ahead and repost the links to them:

Chronic Sinus Problems? Try the Bulletproof Sinus Rinse

Learn the Right Way To Do Hydrogen Peroxide Inhalation Method for Viruses, COPD, Congestion

 

[Wayne]

A good friend of mine has gotten into the habit of immediately taking his clothes off when he gets home, and throwing them in the dryer at high temperature for about 10 minutes. Makes a whole lot of sense to me. I'd sure like to see a lot more these kinds of common sense recommendations being made by public health officials.

I don't know why, if people sanitized their sinuses and clothes upon first getting home, this pandemic couldn't be over in pretty short order. And then if you added Vit. C, and perhaps a variety of oxygenation therapies (like the hydrogen peroxide inhalation technique), and a few other natural antivirals, it could be over even quicker.

 

[anne_likes_red]

I got some povidone iodine yesterday (the strong solution that needs diluting) and I noticed in the instructions for gargling it says not to use it with hydrogen peroxide as this compromises the effectiveness of both. Just mentioning in case anyone is thinking of throwing everything at their symptoms at the same time!

I tried Dave Asprey's "Bulletproof" sinus rinse last night. Thanks for the link Wayne.
My sinuses felt very clear afterwards but I could not get the rinse to come out of my mouth. My technique obviously requires some refinement.

 

[Hip]

I've archived the newly linked video to google drive

The idea of killing coronavirus with hot air appears to be... just a lot of hot air: this study found hot air from a sauna had no effect on the common cold whatsoever. And three studies found no benefit from heated humidified air in treating the common cold.

It's good that YouTube are taking down this sort of misinformation.

 

[Hip]

With YouTube, if you get a million hits on your video, you can earn around $3000 in advertising fees. That's because YouTube pay video owners around $3 in fees per 1000 ad views. Ref: here.

And if your YouTube video gets 10 million views, you can earn £30,000 in advertising.

Therefore at a time like this, where billions of people are searching for answers to coronavirus, people may be uploading any old video to try to cash in. This is why it's good that YouTube are actively removing dubious content.

 

[Hipsman]

With YouTube, if you get a million hits on your video, you can earn around $3000 in advertising fees.

That's true if the video is advertiser friendly, but YouTube marks any video witch mentions "coronavirus" as controversial and there is no adds on these videos, thou it may generate some revenue if it was made before YT started marking these videos as controversial.

This seemed legit to me b/c it is similar to an old practice of putting boiled egg or a small beg of salt with temperature around 60 °C around sinuses for treatment of common cold. My grandparents use this sometimes.

I found this Hot air therapy to have a nice effect on the sinus area, like a "cleared brain" feeling, so I will try it for common cold in the future.

But this most likely doesn't have any effect on Covide-19 should not be used for prevention of Covid-19.

 

[tdog333]

Started feeling a bit sick today. Anyone have information on gargling and applying iodine to the nasal passages?

I found betadine has an oral rinse that is 1% solution, so I made about a 0.7% solution and gargled with it, but it burned my throat a bit. Is that expected or user error? Any information on how often to gargle/swab (if swabbing is a good idea)?

Thank you

 

[frozenborderline]

There is a petition that people may like to sign to restart research into DRACO, the universal antiviral drug designed to work for nearly all viruses.

www.businessinsider.com/todd-rider-draco-crowdfunding-broad-spectrum-antiviral-2015-12

https://en.wikipedia.org/wiki/DRACO

Wow. This is really intriguing. Has anyone shown this to the omf people ?

 

[Hip]

Wow. This is really intriguing. Has anyone shown this to the omf people ?

I am not sure if OMF have seen it. There's been a few threads on the DRACO antiviral in the past.

 

[Wayne]

Anyone have information on gargling and applying iodine to the nasal passages?

@tdog333 -- I ran into the following information a couple days ago:

"The initial upper respiratory infection ALWAYS starts in the nose and sinuses. And usually lingers there for two days to as long as two weeks before progressing. And it is here--within the sinuses--that the invading virus is most easily defeated...by applying external heat."​

I happen to think that the Hydrogen Peroxide Inhalation Method, and the Sinus Cleanse using iodine drops would likely be equally effective as applying external heat. But if not, it would seem they would at least augment the external heat therapy. Here are a couple links to short videos that describe some pretting intriguing therapies.

Chronic Sinus Problems? Try the Bulletproof Sinus Rinse

Learn the Right Way To Do Hydrogen Peroxide Inhalation Method for Viruses, COPD, Congestion

 

[frozenborderline]

@Hip do u have any info on the uk home antibody tests ? How effective they are, when they will be rolled out, how many people will get them, etc?

 

[junkcrap50]

I happen to think that the Hydrogen Peroxide Inhalation Method, and the Sinus Cleanse using iodine drops I mentioned earlier would likely be equally effective.

Putting Johnson and Johnson's baby shampoo in the sinus rinse (a common sinus rinse technique) may also be effective against Coronavirus in the nasal passages.

I don't know why, if people sanitized their sinuses and clothes upon first getting home, this pandemic couldn't be over in pretty short order.

Imagine if all doctors in a hospital were required to do this before and after their shifts. Or have a nasal spray bottle that contained iodine solution they used throughout their shift. It might make a difference over non-rinsed frontline workers. It'd be interesting.

 

[Wally]

I am not sure if this guide from John Hopkins has been posted elsewhere, but it is filled with info. about the virus. Posting it here for the drug info..(antivirals* and immunomodulators), but it is worth reviewing the whole document if you are interested in a fairly comprehensive overview of info. about the virus. This is an updated version from 3/27/2020.
(*Note there is no mention of Vitamin C.)

https://www.hopkinsguides.com/hopki.../540747/all/Coronavirus_COVID_19__SARS_CoV_2_

Antivirals and immunomodulators

• No proven efficacy of any drug for humans as of March 23, 2020.
  
  • Chinese Guidelines for COVID-19 suggest using chloroquine, traditional Chinese medicines, and for anti-IL6R drug tocilizumab as an anti-inflammatory in patients with extensive lung disease/severe illness and elevated IL-6 levels. These recommendations are not yet supported by robust clinical evidence.
  • Lopinavir / ritonavir (LPV/RTV) widely used in China; however, COVID RCT in hospitalized patients yielded no benefit[6].
• A large number of antivirals and immunomodulators are being investigated for treatment or prophylaxis.
  
  • Caution is advised as to whether any are effective or safe for COVID-19.
    
    • If a clinical trial available, consider enrolling patients rather than prescribing off-label drug use to assist in understanding whether intervention is efficacious for COVID-19.
  • Types of drugs under investigation include antivirals (protease inhibitors, influenza drugs, nucleoside analogs) anti-inflammatories, surface protein antagonists such as lecithins.
  • Much like with influenza, antiviral drugs if effective, likely need to be started early in infection course, or used as a preventative.
• Drugs currently under investigation[18]:

• Remdesivir (Gilead; used to treat Ebola)
  
  • Currently under study in a trial in Wuhan and U.S.; activity is seen in vitro with SARS-2-CoV, MERS-CoV (also including MERS-CoV primate studies)
  • Likely the most promising drugl
  • Drug has been used in the U.S. under compassionate use; however, unclear how long this will last
• Chloroquine (or hydroxychloroquine; HCQ) has been reported to have some efficacy in vivo and in limited, very low-quality evidence for COVID-19 pneumonia, the mechanism may be by interfering with cellular acidification in the phagolysosome.[10],[11]
  
  • Gautret et al. suggest decreased SARS-CoV-2 shedding in 6 patients in a post-hoc analysis if HCQ is combined with azithromycin in non-RCT of 36 patients.[21] Small sample size and lack of clinical correlation mean clinicians ought to not base decisions on these limited results.
  • Chloroquine generally unavailable in the U.S., many reporting shortages of hydroxychloroquine.
• ASC09/ritonavir, lopinavir/ritonavir, with or without umifenovir (not available in U.S.)
  
  • Negative Clinical trial using LPV/RTV in hospitalized patients with COVID-19[6]
• ASC09/oseltamivir, ritonavir/oseltamivir, oseltamivir
• 
  
• pAzvudine
• Baloxavir marboxil/favipiravir and LPV/RTV in combination(s)
• Favipiravir (aka T-705, Avigan, or favilavir)
• Zinc
• Indomethacin
• Camostat mesylate
• Darunavir/cobicistat alone or with lopinavir/ritonavir and thymosin α1 in combination(s)
• Interferon alfa-2b alone or in combination with LPV/RTV and ribavirin
• Methylprednisolone
• Camrelizumab and thymosin
• Tocilizumab and other IL-6 inhibitors
• Convalescent sera (from recovered COVID-19 patients)
• Monoclonal antibodies, specific to SARS-CoV-2