Lately several antibodies targeting the receptors IL4, IL13 and IL5 have been approved for a range of conditions : asthma, eczema and chronic rhinosinusitis. These new treatments efficiently down regulate Th2 mediated inflammation and relieve symptoms. They work best for people who have an eosinophils blood count higher than 300 cells/mm3 (0.3 x10^9/L). Another Th2 inflammation suppressing antibody in the work is Lenzilumab, which targets GM-CSF and indirectly reduce the count of several monokines such MCP-1, MIP-1⍺, MIG, IP-10 and IL-1, Some shown to be elevated in ME/CFS serum and/or correlate with ME/CFS severity. Lenzilumab has shown a lot of promise in treating COVID-19 cytokine storm and is currently in phase 3 trial for this condition. Lenzilumab appear to not only relieve the cytokine storm but also speed up viral clearance. (Shifting from Th2 to Th1?)
Seeing that none of the traditional immune suppressants has yet to work for ME/CFS, and the only immune suppressant that has shown any signal to date is the highly potent and non-selective cyclophosphamide, maybe the next step for an attempt at immune suppression for ME/CFS is a cocktail of these new generation Th2 directed immune suppressants. It may not cure ME/CFS but it may reduce symptoms further and relieve some of the fatigue.
What is your blood eosinophils count and do you have some symptoms such as occasional asthma-like difficulty breathing and itching from taking a shower? I certainly do and my eosinophils count is 380.
Anti IL4/13: Dupilumab; Anti-IL5: Benralizumab, Anti-GM-CSF: Lenzilumab. All very expensive.
Seeing that none of the traditional immune suppressants has yet to work for ME/CFS, and the only immune suppressant that has shown any signal to date is the highly potent and non-selective cyclophosphamide, maybe the next step for an attempt at immune suppression for ME/CFS is a cocktail of these new generation Th2 directed immune suppressants. It may not cure ME/CFS but it may reduce symptoms further and relieve some of the fatigue.
What is your blood eosinophils count and do you have some symptoms such as occasional asthma-like difficulty breathing and itching from taking a shower? I certainly do and my eosinophils count is 380.
Anti IL4/13: Dupilumab; Anti-IL5: Benralizumab, Anti-GM-CSF: Lenzilumab. All very expensive.
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