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@stridorYes, you have to tag me for me to be notified and that is still no guarantee. Lots of times I only find out that someone has tried to reach me after the fact.
My angular cheilitis was at the corners of my mouth and I had a rash on my left jawline, tip of my nose and "down there". I also had huge, angry capillaries circling my pupils. That was the second time. The first, was a swollen and split tongue.
I have been wanting to write you for the past 2 weeks, but have been too messed up, especially in my brain. I did finally read your B2 thread when I was more coherent, and I feel embarrassed about complaining about my stuff after reading about yours! You have really been through a lot. Btw, I showed my doc my split lip and he doesn't think it's angular cheilitis.
Anyway I tried everything from changing the dose of the shot from 100-300 mcg, to trying 2 shots a day, to adding various doses of MFolate and SL MB12 during the day. I have settled on 100 mcg injection at 7pm with 1,700 mcg MF (incl 100 mcg MF in my B Complex and 3,000 mcg AdB12), which is too strong some days and not enough on others, with no add'l MF or MB during the day. I don't know why some days 100 mcg seems too strong and other days I get exhausted by the afternoon. Maybe it has something to do with hormone fluctuations. I got really depressed last week during pms time. Today I felt weird jittery surges from late morning until late aftn for no apparent reason (although it was made worse by my not eating until mid afternoon). The jitteriness resulted in me also having tightness in my chest and more constricted breathing at times, where I couldn't take a deep breath.
Sometimes being so hyper names me feel really anxious too, but the brain stuff is the worse. Unfortunately more MF only helps a little and briefly if at all, and if I don't take SL MB within an hour of taking MF, I feel really sick and queasy all over. However if I take SL MB, then I get more amped up and jittery than ever! For some reason I am also more sensitive to LCF now too. It used to make me feel great, and now it either makes me too jittery or doesn't work at all!
This is the most stressful time of the year for me, but for a couple of weeks since the shots I just felt kind of down most of the time, which is not like me. I would forget things I had done just minutes after doing them. I felt more anxious around people, and almost blacked out at the wheel 3x one aftn. Have made other very bad judgements while driving too, got confused about what kind of gas I use, and forgot to lock my car when I went to Costco---all completely unlike me. I am usually very precise and methodical. I started constantly second guessing everything I do, and OCD type behaviors got much worse. All this was starting to make me feel a little nuts! Thankfully I think it's getting a little better.
I find I can tolerate things better at night, which is why I take everything at night now. Also I feel pretty good about the 100 mcg shot dose, since @Freddd says 100mcg absorbed of MB opens almost all layers of healing. He also says that any time he's having symptoms somewhere often means healing is taking place. I have been having brief migrating pains in sciatica and elsewhere in butt/legs for no apparent reason, that cone on suddenly, sometimes last a day or two, and then just disappear.
I did a lot of research and some of my symptoms sounded like what Rich Van Konynenburg called excitotoxicity. Many symptoms could also be overmethylation. Lotus had a post in the "hydroxocobalamin vs methylcobalamin" thread that said those with COMT/VDR snp's (like me) could be more prone to overmethylation.
Although I think you thought I might be more undermethylated (but maybe not now after the shots!).
In Amy Yasko's chart for "B12 Types That Should be Tolerated" it says those with both COMT V158M +/- and VDR Taq +/- (like me) should tolerate Hydroxy and AdB12. Funny because it took a long time for me to tolerate AdB12. I did ok on Hydroxy shots 10 years ago, but I don't remember exactly how they made me feel, and that was before we knew about methylation (It was high doses of folic acid that made me B12 deficient, as I previously told you.) Many people on the forum don't think much of Yasko's findings though, including @Freddd
My MB shot dose might still just be too high, though I think I am slowly starting to adapt. That could be triggering excessive inflammation (like those migrating pains) or a detox of heavy metals, as some of the recent brain issues reminded me of how I felt after the EDTA chelation made me reabsorb some of the arsenic, probably mostly in my brain! I couldn't think straight for over a year, and still didn't feel back to normal even before the MB shots.
Do you think I should try 50 or 75 mcg instead? I could probably eyeball those doses, but then I might get more tired in the afternoons.
After 4 weeks of not feeling like myself anymore I was ready to try hydroxy injections instead, but after doing more research I don't know if I should. There is heated debate about it on the forum, but Freddd makes quite a case for staying with methylB12 in several posts on this page:
http://forums.phoenixrising.me/index.php?threads/methylcobalamin-vs-hydroxocobalamin.22173/
I certainly don't want to go backwards, or take something less active like Hydroxy unless as a last resort. I really appreciate your thoughts on this!