From my extensive reading of the forums here on the Fredd Protocol, I don't recall any mention of a "proper" ratio between adeno and methyl. It's all dependent on the person and how one feels to increasing their dosages. So, I wouldn't worry about that. However, if you increased your dose from 2mg to 10mg adenosyl at once, then that's a big jump up and big change. That's far too much, far too fast. If you did, I would go back to 2mg of adenosyl.
From my reading on the forums, I had understood that one should increase all their DQ levels first to 1,000mcg/mg before going above that. However, reaching that conclusion took A LOT of reading and A LOT of confusion, especially since Fredd didn't recommend that until more recently, after he had already developed the protocol and gave recommendations. So, I would titrate your LCF dose up to 1,000mg first before adjusting adenosyl and methyl.
Thirdly, depression may be a low methylfolate issue. Other symptoms are more common for early signs of low methylfolate, but everyone is different. Not everyone gets angular cheilitis or other mouth symptoms first. So, depression may be more common for you. In addition, methylfolate in large doses is often used to treat depression, which is what prescription Deplin is used for. So, upping your methylfolate may help your depression. (Maybe the larger adenosyl caused low folate).
Lastly, when all else fails, I look to cofactors. I couldn't tell you for sure which ones, but I think the importane of B-vitamins (B1, B2, B3, B6) are understated by Fredd and others as cofactors. Very recently, I had some depression come up while playing around with B1 and B3 cofactors, when trying to address headaches. And in trying 1 dosage of P-5-P (B6) seemed to help that day with the depresssion. I haven't be able to confirm it or say P-5-P helped me with it, but I mention it as a hunch I have (at least for myself).
Hope this helps you
PS: I'm soon placing an order on the B12 oils and am going to get the adenosyl and methyl separately. Since Fredd says the adenosyl can be stored somewhat in reserve in mitochondria (hence can be taking only 1x/week), then perhaps the sublingual adenosyl is okay to take without worry of consistent absoprtion. While methyl B12 needs a more constant and consistent delivery of dosing, the B12 oil is better than the sublingual for that particular form. You could always play with taking one type of b12 as an oil and another as a sublingual. That's what I plan on doing while playing around with it.
) and I've also got a voracious appetite for B12 -- when I was using sublinguals I used almost as much as you. Greg has never figured out why I need so much.
